Silver-catalyzed remote Csp(3)-H functionalization of aliphatic alcohols

Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyzed δ-selective Csp(3)-H bond functionalization of abundant and inexpensive aliphatic alcoho...

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Detalles Bibliográficos
Autores principales: Zhu, Yuchao, Huang, Kaimeng, Pan, Jun, Qiu, Xu, Luo, Xiao, Qin, Qixue, Wei, Jialiang, Wen, Xiaojin, Zhang, Lizhi, Jiao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035238/
https://www.ncbi.nlm.nih.gov/pubmed/29980674
http://dx.doi.org/10.1038/s41467-018-05014-w
Descripción
Sumario:Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyzed δ-selective Csp(3)-H bond functionalization of abundant and inexpensive aliphatic alcohols. Valuable oximonitrile substituted alcohols are easily obtained by using well-designed sulphonyl reagents under simple and mild conditions. This protocol realizes the challenging δ-selective C–C bond formation of simple alkanols.

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