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Role of inter-hemispheric connections in functional brain networks
Today the human brain can be modeled as a graph where nodes represent different regions and links stand for statistical interactions between their activities as recorded by different neuroimaging techniques. Empirical studies have lead to the hypothesis that brain functions rely on the coordination...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035280/ https://www.ncbi.nlm.nih.gov/pubmed/29980771 http://dx.doi.org/10.1038/s41598-018-28467-x |
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author | Martínez, J. H. Buldú, J. M. Papo, D. Fallani, F. De Vico Chavez, M. |
author_facet | Martínez, J. H. Buldú, J. M. Papo, D. Fallani, F. De Vico Chavez, M. |
author_sort | Martínez, J. H. |
collection | PubMed |
description | Today the human brain can be modeled as a graph where nodes represent different regions and links stand for statistical interactions between their activities as recorded by different neuroimaging techniques. Empirical studies have lead to the hypothesis that brain functions rely on the coordination of a scattered mosaic of functionally specialized brain regions (modules or sub-networks), forming a web-like structure of coordinated assemblies (a network of networks. NoN). The study of brain dynamics would therefore benefit from an inspection of how functional sub-networks interact between them. In this paper, we model the brain as an interconnected system composed of two specific sub-networks, the left (L) and right (R) hemispheres, which compete with each other for centrality, a topological measure of importance in a networked system. Specifically, we considered functional scalp EEG networks (SEN) derived from high-density electroencephalographic (EEG) recordings and investigated how node centrality is shaped by interhemispheric connections. Our results show that the distribution of centrality strongly depends on the number of functional connections between hemispheres and the way these connections are distributed. Additionally, we investigated the consequences of node failure on hemispherical centrality, and showed how the abundance of inter-hemispheric links favors the functional balance of centrality distribution between the hemispheres. |
format | Online Article Text |
id | pubmed-6035280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60352802018-07-12 Role of inter-hemispheric connections in functional brain networks Martínez, J. H. Buldú, J. M. Papo, D. Fallani, F. De Vico Chavez, M. Sci Rep Article Today the human brain can be modeled as a graph where nodes represent different regions and links stand for statistical interactions between their activities as recorded by different neuroimaging techniques. Empirical studies have lead to the hypothesis that brain functions rely on the coordination of a scattered mosaic of functionally specialized brain regions (modules or sub-networks), forming a web-like structure of coordinated assemblies (a network of networks. NoN). The study of brain dynamics would therefore benefit from an inspection of how functional sub-networks interact between them. In this paper, we model the brain as an interconnected system composed of two specific sub-networks, the left (L) and right (R) hemispheres, which compete with each other for centrality, a topological measure of importance in a networked system. Specifically, we considered functional scalp EEG networks (SEN) derived from high-density electroencephalographic (EEG) recordings and investigated how node centrality is shaped by interhemispheric connections. Our results show that the distribution of centrality strongly depends on the number of functional connections between hemispheres and the way these connections are distributed. Additionally, we investigated the consequences of node failure on hemispherical centrality, and showed how the abundance of inter-hemispheric links favors the functional balance of centrality distribution between the hemispheres. Nature Publishing Group UK 2018-07-06 /pmc/articles/PMC6035280/ /pubmed/29980771 http://dx.doi.org/10.1038/s41598-018-28467-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Martínez, J. H. Buldú, J. M. Papo, D. Fallani, F. De Vico Chavez, M. Role of inter-hemispheric connections in functional brain networks |
title | Role of inter-hemispheric connections in functional brain networks |
title_full | Role of inter-hemispheric connections in functional brain networks |
title_fullStr | Role of inter-hemispheric connections in functional brain networks |
title_full_unstemmed | Role of inter-hemispheric connections in functional brain networks |
title_short | Role of inter-hemispheric connections in functional brain networks |
title_sort | role of inter-hemispheric connections in functional brain networks |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035280/ https://www.ncbi.nlm.nih.gov/pubmed/29980771 http://dx.doi.org/10.1038/s41598-018-28467-x |
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