Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR

Phosphatidylinositol phospholipase Cγ (PLCγ) is an intracellular membrane-associated second-messenger signaling protein activated by tyrosine kinases such as fibroblast growth factor receptor 1. PLCγ contains the regulatory γ-specific array (γSA) comprising a tandem Src homology 2 (SH2) pair, an SH3...

Descripción completa

Detalles Bibliográficos
Autores principales: Koss, Hans, Bunney, Tom D., Esposito, Diego, Martins, Marta, Katan, Matilda, Driscoll, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2018
Materias:
Proteins
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035297/
https://www.ncbi.nlm.nih.gov/pubmed/29972810
http://dx.doi.org/10.1016/j.bpj.2018.05.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035297/
https://www.ncbi.nlm.nih.gov/pubmed/29972810
http://dx.doi.org/10.1016/j.bpj.2018.05.031

Ejemplares similares