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Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR

Phosphatidylinositol phospholipase Cγ (PLCγ) is an intracellular membrane-associated second-messenger signaling protein activated by tyrosine kinases such as fibroblast growth factor receptor 1. PLCγ contains the regulatory γ-specific array (γSA) comprising a tandem Src homology 2 (SH2) pair, an SH3...

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Detalles Bibliográficos
Autores principales:	Koss, Hans, Bunney, Tom D., Esposito, Diego, Martins, Marta, Katan, Matilda, Driscoll, Paul C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society 2018
Materias:	Proteins
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035297/ https://www.ncbi.nlm.nih.gov/pubmed/29972810 http://dx.doi.org/10.1016/j.bpj.2018.05.031

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