Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes

BACKGROUND: High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggests that inhibition may be useful therapeutically. Inhibition of HOX protein bind...

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Detalles Bibliográficos
Autores principales: Platais, Christopher, Radhakrishnan, Raghu, Ebensberger, Sven Niklander, Morgan, Richard, Lambert, Daniel W., Hunter, Keith D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035449/
https://www.ncbi.nlm.nih.gov/pubmed/29980182
http://dx.doi.org/10.1186/s12885-018-4622-0

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