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Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions
OBJECTIVE: MicroRNA (miR)-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism. A recent study reported that miR-122 plays a role in pathogenesis of atherosclerosis; however, whether it connects with severity of atherosclerotic lesion is still co...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035718/ https://www.ncbi.nlm.nih.gov/pubmed/30013851 http://dx.doi.org/10.7717/peerj.5218 |
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author | Wang, Yu-Long Yu, Wen |
author_facet | Wang, Yu-Long Yu, Wen |
author_sort | Wang, Yu-Long |
collection | PubMed |
description | OBJECTIVE: MicroRNA (miR)-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism. A recent study reported that miR-122 plays a role in pathogenesis of atherosclerosis; however, whether it connects with severity of atherosclerotic lesion is still controversial. We therefore investigated the association between miR-122 expression and presence and severity of coronary atherosclerotic plaque. METHODS: During January–November 2017, we included 300 patients with coronary heart disease (CHD) and 100 subjects as the control group. MiR-122 content was detected by quantitative real-time polymerase chain reaction. MiR-122 level was identified in all subjects, and the Spearman correlation between miR-122 and severity of atherosclerosis was analyzed. RESULTS: Patients with CHD had higher miR-122 expression than in control group (2.61, 0.91–8.86 vs. 1.62, 0.71–3.45, p < 0.001). Gensini score was significantly associated with miR-122 expression (r = 0.7964, p < 0.001). The odds ratio of miR-122 solely was 0.12 (95% CI [0.05–0.43]) and factors such as cholesterol, triglyceride together with miR-122 level were closely associated with atherosclerosis (all p < 0.001). CONCLUSIONS: The serum level of miR-122 may be used to differentiate between mild and severe coronary atherosclerotic lesion. Use of this marker might allow non-invasive diagnosis the degree of coronary atherosclerosis. |
format | Online Article Text |
id | pubmed-6035718 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60357182018-07-16 Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions Wang, Yu-Long Yu, Wen PeerJ Cardiology OBJECTIVE: MicroRNA (miR)-122 is highly expressed in the liver, where it has been implicated as a regulator of fatty-acid metabolism. A recent study reported that miR-122 plays a role in pathogenesis of atherosclerosis; however, whether it connects with severity of atherosclerotic lesion is still controversial. We therefore investigated the association between miR-122 expression and presence and severity of coronary atherosclerotic plaque. METHODS: During January–November 2017, we included 300 patients with coronary heart disease (CHD) and 100 subjects as the control group. MiR-122 content was detected by quantitative real-time polymerase chain reaction. MiR-122 level was identified in all subjects, and the Spearman correlation between miR-122 and severity of atherosclerosis was analyzed. RESULTS: Patients with CHD had higher miR-122 expression than in control group (2.61, 0.91–8.86 vs. 1.62, 0.71–3.45, p < 0.001). Gensini score was significantly associated with miR-122 expression (r = 0.7964, p < 0.001). The odds ratio of miR-122 solely was 0.12 (95% CI [0.05–0.43]) and factors such as cholesterol, triglyceride together with miR-122 level were closely associated with atherosclerosis (all p < 0.001). CONCLUSIONS: The serum level of miR-122 may be used to differentiate between mild and severe coronary atherosclerotic lesion. Use of this marker might allow non-invasive diagnosis the degree of coronary atherosclerosis. PeerJ Inc. 2018-07-04 /pmc/articles/PMC6035718/ /pubmed/30013851 http://dx.doi.org/10.7717/peerj.5218 Text en © 2018 Wang and Yu http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Cardiology Wang, Yu-Long Yu, Wen Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions |
title | Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions |
title_full | Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions |
title_fullStr | Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions |
title_full_unstemmed | Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions |
title_short | Association of circulating microRNA-122 with presence and severity of atherosclerotic lesions |
title_sort | association of circulating microrna-122 with presence and severity of atherosclerotic lesions |
topic | Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035718/ https://www.ncbi.nlm.nih.gov/pubmed/30013851 http://dx.doi.org/10.7717/peerj.5218 |
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