Identification of Epigenetic Regulators of DUX4-fl for Targeted Therapy of Facioscapulohumeral Muscular Dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is caused by epigenetic de-repression of the disease locus, leading to pathogenic misexpression of the DUX4 gene in skeletal muscle. While the factors and pathways involved in normal repression of the FSHD locus in healthy cells have been well characteri...

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Detalles Bibliográficos
Autores principales: Himeda, Charis L., Jones, Takako I., Virbasius, Ching-Man, Zhu, Lihua Julie, Green, Michael R., Jones, Peter L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035737/
https://www.ncbi.nlm.nih.gov/pubmed/29759937
http://dx.doi.org/10.1016/j.ymthe.2018.04.019

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