Cargando…

Deciphering Non-coding RNAs in Cardiovascular Health and Disease

After being long considered as “junk” in the human genome, non-coding RNAs (ncRNAs) currently represent one of the newest frontiers in cardiovascular disease (CVD) since they have emerged in recent years as potential therapeutic targets. Different types of ncRNAs exist, including small ncRNAs that h...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Anindita, Samidurai, Arun, Salloum, Fadi N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036139/
https://www.ncbi.nlm.nih.gov/pubmed/30013975
http://dx.doi.org/10.3389/fcvm.2018.00073
_version_ 1783338112497221632
author Das, Anindita
Samidurai, Arun
Salloum, Fadi N.
author_facet Das, Anindita
Samidurai, Arun
Salloum, Fadi N.
author_sort Das, Anindita
collection PubMed
description After being long considered as “junk” in the human genome, non-coding RNAs (ncRNAs) currently represent one of the newest frontiers in cardiovascular disease (CVD) since they have emerged in recent years as potential therapeutic targets. Different types of ncRNAs exist, including small ncRNAs that have fewer than 200 nucleotides, which are mostly known as microRNAs (miRNAs), and long ncRNAs that have more than 200 nucleotides. Recent discoveries on the role of ncRNAs in epigenetic and transcriptional regulation, atherosclerosis, myocardial ischemia/reperfusion (I/R) injury and infarction (MI), adverse cardiac remodeling and hypertrophy, insulin resistance, and diabetic cardiomyopathy prompted vast interest in exploring candidate ncRNAs for utilization as potential therapeutic targets and/or diagnostic/prognostic biomarkers in CVDs. This review will discuss our current knowledge concerning the roles of different types of ncRNAs in cardiovascular health and disease and provide some insight on the cardioprotective signaling pathways elicited by the non-coding genome. We will highlight important basic and clinical breakthroughs that support employing ncRNAs for treatment or early diagnosis of a variety of CVDs, and also depict the most relevant limitations that challenge this novel therapeutic approach.
format Online
Article
Text
id pubmed-6036139
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-60361392018-07-16 Deciphering Non-coding RNAs in Cardiovascular Health and Disease Das, Anindita Samidurai, Arun Salloum, Fadi N. Front Cardiovasc Med Cardiovascular Medicine After being long considered as “junk” in the human genome, non-coding RNAs (ncRNAs) currently represent one of the newest frontiers in cardiovascular disease (CVD) since they have emerged in recent years as potential therapeutic targets. Different types of ncRNAs exist, including small ncRNAs that have fewer than 200 nucleotides, which are mostly known as microRNAs (miRNAs), and long ncRNAs that have more than 200 nucleotides. Recent discoveries on the role of ncRNAs in epigenetic and transcriptional regulation, atherosclerosis, myocardial ischemia/reperfusion (I/R) injury and infarction (MI), adverse cardiac remodeling and hypertrophy, insulin resistance, and diabetic cardiomyopathy prompted vast interest in exploring candidate ncRNAs for utilization as potential therapeutic targets and/or diagnostic/prognostic biomarkers in CVDs. This review will discuss our current knowledge concerning the roles of different types of ncRNAs in cardiovascular health and disease and provide some insight on the cardioprotective signaling pathways elicited by the non-coding genome. We will highlight important basic and clinical breakthroughs that support employing ncRNAs for treatment or early diagnosis of a variety of CVDs, and also depict the most relevant limitations that challenge this novel therapeutic approach. Frontiers Media S.A. 2018-07-02 /pmc/articles/PMC6036139/ /pubmed/30013975 http://dx.doi.org/10.3389/fcvm.2018.00073 Text en Copyright © 2018 Das, Samidurai and Salloum. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Das, Anindita
Samidurai, Arun
Salloum, Fadi N.
Deciphering Non-coding RNAs in Cardiovascular Health and Disease
title Deciphering Non-coding RNAs in Cardiovascular Health and Disease
title_full Deciphering Non-coding RNAs in Cardiovascular Health and Disease
title_fullStr Deciphering Non-coding RNAs in Cardiovascular Health and Disease
title_full_unstemmed Deciphering Non-coding RNAs in Cardiovascular Health and Disease
title_short Deciphering Non-coding RNAs in Cardiovascular Health and Disease
title_sort deciphering non-coding rnas in cardiovascular health and disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036139/
https://www.ncbi.nlm.nih.gov/pubmed/30013975
http://dx.doi.org/10.3389/fcvm.2018.00073
work_keys_str_mv AT dasanindita decipheringnoncodingrnasincardiovascularhealthanddisease
AT samiduraiarun decipheringnoncodingrnasincardiovascularhealthanddisease
AT salloumfadin decipheringnoncodingrnasincardiovascularhealthanddisease