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Cysteine-Reactive Free ISG15 Generates IL-1β–Producing CD8α(+) Dendritic Cells at the Site of Infection

IFN-stimulated gene (ISG) 15 is a ubiquitin-like protein induced after type I IFN stimulation. There is a dearth of in vivo models to study free unconjugated ISG15 function. We found that free ISG15 enhances the production of IFN-γ and IL-1β during murine infection with Toxoplasma gondii. In our mod...

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Detalles Bibliográficos
Autores principales:	Napolitano, Anna, van der Veen, Annemarthe G., Bunyan, Monique, Borg, Annabel, Frith, David, Howell, Steven, Kjaer, Svend, Beling, Antje, Snijders, Ambrosius P., Knobeloch, Klaus-Peter, Frickel, Eva-Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2018
Materias:	Infectious Disease and Host Response
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036233/ https://www.ncbi.nlm.nih.gov/pubmed/29891555 http://dx.doi.org/10.4049/jimmunol.1701322

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