Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease

Cardiovascular health is a primary research focus, as it is a leading contributor to mortality and morbidity worldwide, and is prohibitively costly for healthcare. Atherosclerosis, the main driver of cardiovascular disease, is now recognized as an inflammatory disorder. Physical activity (PA) may ha...

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Autores principales: Fernandez, Dawn M., Clemente, Jose C., Giannarelli, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036301/
https://www.ncbi.nlm.nih.gov/pubmed/30013482
http://dx.doi.org/10.3389/fphys.2018.00763
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author Fernandez, Dawn M.
Clemente, Jose C.
Giannarelli, Chiara
author_facet Fernandez, Dawn M.
Clemente, Jose C.
Giannarelli, Chiara
author_sort Fernandez, Dawn M.
collection PubMed
description Cardiovascular health is a primary research focus, as it is a leading contributor to mortality and morbidity worldwide, and is prohibitively costly for healthcare. Atherosclerosis, the main driver of cardiovascular disease, is now recognized as an inflammatory disorder. Physical activity (PA) may have a more important role in cardiovascular health than previously expected. This review overviews the contribution of PA to cardiovascular health, the inflammatory role of atherosclerosis, and the emerging evidence of the microbiome as a regulator of inflammation.
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spelling pubmed-60363012018-07-16 Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease Fernandez, Dawn M. Clemente, Jose C. Giannarelli, Chiara Front Physiol Physiology Cardiovascular health is a primary research focus, as it is a leading contributor to mortality and morbidity worldwide, and is prohibitively costly for healthcare. Atherosclerosis, the main driver of cardiovascular disease, is now recognized as an inflammatory disorder. Physical activity (PA) may have a more important role in cardiovascular health than previously expected. This review overviews the contribution of PA to cardiovascular health, the inflammatory role of atherosclerosis, and the emerging evidence of the microbiome as a regulator of inflammation. Frontiers Media S.A. 2018-06-29 /pmc/articles/PMC6036301/ /pubmed/30013482 http://dx.doi.org/10.3389/fphys.2018.00763 Text en Copyright © 2018 Fernandez, Clemente and Giannarelli. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Fernandez, Dawn M.
Clemente, Jose C.
Giannarelli, Chiara
Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease
title Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease
title_full Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease
title_fullStr Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease
title_full_unstemmed Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease
title_short Physical Activity, Immune System, and the Microbiome in Cardiovascular Disease
title_sort physical activity, immune system, and the microbiome in cardiovascular disease
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036301/
https://www.ncbi.nlm.nih.gov/pubmed/30013482
http://dx.doi.org/10.3389/fphys.2018.00763
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