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The impact of robustness of deformable image registration on contour propagation and dose accumulation for head and neck adaptive radiotherapy

Deformable image registration (DIR) is the key process for contour propagation and dose accumulation in adaptive radiation therapy (ART). However, currently, ART suffers from a lack of understanding of “robustness” of the process involving the image contour based on DIR and subsequent dose variation...

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Autores principales: Zhang, Lian, Wang, Zhi, Shi, Chengyu, Long, Tengfei, Xu, X. George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036371/
https://www.ncbi.nlm.nih.gov/pubmed/29851267
http://dx.doi.org/10.1002/acm2.12361
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author Zhang, Lian
Wang, Zhi
Shi, Chengyu
Long, Tengfei
Xu, X. George
author_facet Zhang, Lian
Wang, Zhi
Shi, Chengyu
Long, Tengfei
Xu, X. George
author_sort Zhang, Lian
collection PubMed
description Deformable image registration (DIR) is the key process for contour propagation and dose accumulation in adaptive radiation therapy (ART). However, currently, ART suffers from a lack of understanding of “robustness” of the process involving the image contour based on DIR and subsequent dose variations caused by algorithm itself and the presetting parameters. The purpose of this research is to evaluate the DIR caused variations for contour propagation and dose accumulation during ART using the RayStation treatment planning system. Ten head and neck cancer patients were selected for retrospective studies. Contours were performed by a single radiation oncologist and new treatment plans were generated on the weekly CT scans for all patients. For each DIR process, four deformation vector fields (DVFs) were generated to propagate contours and accumulate weekly dose by the following algorithms: (a) ANACONDA with simple presetting parameters, (b) ANACONDA with detailed presetting parameters, (c) MORFEUS with simple presetting parameters, and (d) MORFEUS with detailed presetting parameters. The geometric evaluation considered DICE coefficient and Hausdorff distance. The dosimetric evaluation included D(95), D(max), D(mean), D(min), and Homogeneity Index. For geometric evaluation, the DICE coefficient variations of the GTV were found to be 0.78 ± 0.11, 0.96 ± 0.02, 0.64 ± 0.15, and 0.91 ± 0.03 for simple ANACONDA, detailed ANACONDA, simple MORFEUS, and detailed MORFEUS, respectively. For dosimetric evaluation, the corresponding Homogeneity Index variations were found to be 0.137 ± 0.115, 0.006 ± 0.032, 0.197 ± 0.096, and 0.006 ± 0.033, respectively. The coherent geometric and dosimetric variations also consisted in large organs and small organs. Overall, the results demonstrated that the contour propagation and dose accumulation in clinical ART were influenced by the DIR algorithm, and to a greater extent by the presetting parameters. A quality assurance procedure should be established for the proper use of a commercial DIR for adaptive radiation therapy.
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spelling pubmed-60363712018-07-12 The impact of robustness of deformable image registration on contour propagation and dose accumulation for head and neck adaptive radiotherapy Zhang, Lian Wang, Zhi Shi, Chengyu Long, Tengfei Xu, X. George J Appl Clin Med Phys Radiation Oncology Physics Deformable image registration (DIR) is the key process for contour propagation and dose accumulation in adaptive radiation therapy (ART). However, currently, ART suffers from a lack of understanding of “robustness” of the process involving the image contour based on DIR and subsequent dose variations caused by algorithm itself and the presetting parameters. The purpose of this research is to evaluate the DIR caused variations for contour propagation and dose accumulation during ART using the RayStation treatment planning system. Ten head and neck cancer patients were selected for retrospective studies. Contours were performed by a single radiation oncologist and new treatment plans were generated on the weekly CT scans for all patients. For each DIR process, four deformation vector fields (DVFs) were generated to propagate contours and accumulate weekly dose by the following algorithms: (a) ANACONDA with simple presetting parameters, (b) ANACONDA with detailed presetting parameters, (c) MORFEUS with simple presetting parameters, and (d) MORFEUS with detailed presetting parameters. The geometric evaluation considered DICE coefficient and Hausdorff distance. The dosimetric evaluation included D(95), D(max), D(mean), D(min), and Homogeneity Index. For geometric evaluation, the DICE coefficient variations of the GTV were found to be 0.78 ± 0.11, 0.96 ± 0.02, 0.64 ± 0.15, and 0.91 ± 0.03 for simple ANACONDA, detailed ANACONDA, simple MORFEUS, and detailed MORFEUS, respectively. For dosimetric evaluation, the corresponding Homogeneity Index variations were found to be 0.137 ± 0.115, 0.006 ± 0.032, 0.197 ± 0.096, and 0.006 ± 0.033, respectively. The coherent geometric and dosimetric variations also consisted in large organs and small organs. Overall, the results demonstrated that the contour propagation and dose accumulation in clinical ART were influenced by the DIR algorithm, and to a greater extent by the presetting parameters. A quality assurance procedure should be established for the proper use of a commercial DIR for adaptive radiation therapy. John Wiley and Sons Inc. 2018-05-30 /pmc/articles/PMC6036371/ /pubmed/29851267 http://dx.doi.org/10.1002/acm2.12361 Text en © 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Zhang, Lian
Wang, Zhi
Shi, Chengyu
Long, Tengfei
Xu, X. George
The impact of robustness of deformable image registration on contour propagation and dose accumulation for head and neck adaptive radiotherapy
title The impact of robustness of deformable image registration on contour propagation and dose accumulation for head and neck adaptive radiotherapy
title_full The impact of robustness of deformable image registration on contour propagation and dose accumulation for head and neck adaptive radiotherapy
title_fullStr The impact of robustness of deformable image registration on contour propagation and dose accumulation for head and neck adaptive radiotherapy
title_full_unstemmed The impact of robustness of deformable image registration on contour propagation and dose accumulation for head and neck adaptive radiotherapy
title_short The impact of robustness of deformable image registration on contour propagation and dose accumulation for head and neck adaptive radiotherapy
title_sort impact of robustness of deformable image registration on contour propagation and dose accumulation for head and neck adaptive radiotherapy
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036371/
https://www.ncbi.nlm.nih.gov/pubmed/29851267
http://dx.doi.org/10.1002/acm2.12361
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