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Implementation of genomic medicine for gastrointestinal tumors

Genomic medicine is an approach to take advantage of genomic data in medical practice and health care. The advancement of sequencing technologies has enabled the determination of individual genomes as well as the genome in neoplasms. In the field of human cancer, understanding genomic alterations in...

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Autor principal: Furukawa, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036382/
https://www.ncbi.nlm.nih.gov/pubmed/30003187
http://dx.doi.org/10.1002/ags3.12178
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author Furukawa, Yoichi
author_facet Furukawa, Yoichi
author_sort Furukawa, Yoichi
collection PubMed
description Genomic medicine is an approach to take advantage of genomic data in medical practice and health care. The advancement of sequencing technologies has enabled the determination of individual genomes as well as the genome in neoplasms. In the field of human cancer, understanding genomic alterations in tumors and variations associated with drug responses has paved the way towards the development of new drugs and personalized medicine. International collaborations of cancer genome analyses have accumulated a huge body of information about somatic mutations, and identified new driver mutations and pathways in a wide range of cancers. In particular, a growing body of evidence has shown that information about mutations in neoplasms helps to assess the efficacy and resistance of anti‐cancer drugs. Information about germline mutations associated with hereditary cancer has been shown to benefit patients by enabling early detection of their tumors and disease‐specific treatment, as well as reducing the risk for those at risk. To promote personalized medicine in a more cost‐effective and personalized way, further inter‐institutional, nationwide, and international collaboration is needed. This article summarizes the background and current situation of genomic medicine in the field of gastrointestinal tumors to help physicians and medical coworkers by assisting their better understanding of genomic medicine and strengthening their confidence of its clinical use.
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spelling pubmed-60363822018-07-12 Implementation of genomic medicine for gastrointestinal tumors Furukawa, Yoichi Ann Gastroenterol Surg Review Article Genomic medicine is an approach to take advantage of genomic data in medical practice and health care. The advancement of sequencing technologies has enabled the determination of individual genomes as well as the genome in neoplasms. In the field of human cancer, understanding genomic alterations in tumors and variations associated with drug responses has paved the way towards the development of new drugs and personalized medicine. International collaborations of cancer genome analyses have accumulated a huge body of information about somatic mutations, and identified new driver mutations and pathways in a wide range of cancers. In particular, a growing body of evidence has shown that information about mutations in neoplasms helps to assess the efficacy and resistance of anti‐cancer drugs. Information about germline mutations associated with hereditary cancer has been shown to benefit patients by enabling early detection of their tumors and disease‐specific treatment, as well as reducing the risk for those at risk. To promote personalized medicine in a more cost‐effective and personalized way, further inter‐institutional, nationwide, and international collaboration is needed. This article summarizes the background and current situation of genomic medicine in the field of gastrointestinal tumors to help physicians and medical coworkers by assisting their better understanding of genomic medicine and strengthening their confidence of its clinical use. John Wiley and Sons Inc. 2018-06-08 /pmc/articles/PMC6036382/ /pubmed/30003187 http://dx.doi.org/10.1002/ags3.12178 Text en © 2018 The Authors. Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Furukawa, Yoichi
Implementation of genomic medicine for gastrointestinal tumors
title Implementation of genomic medicine for gastrointestinal tumors
title_full Implementation of genomic medicine for gastrointestinal tumors
title_fullStr Implementation of genomic medicine for gastrointestinal tumors
title_full_unstemmed Implementation of genomic medicine for gastrointestinal tumors
title_short Implementation of genomic medicine for gastrointestinal tumors
title_sort implementation of genomic medicine for gastrointestinal tumors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036382/
https://www.ncbi.nlm.nih.gov/pubmed/30003187
http://dx.doi.org/10.1002/ags3.12178
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