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HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study
PURPOSE: This study aims to assess the accuracy of source position verification during high‐dose rate (HDR) prostate brachytherapy using a novel, in‐house developed two‐dimensional (2D) diode array (the Magic Plate), embedded exactly below the patient within a carbon fiber couch. The effect of tissu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036394/ https://www.ncbi.nlm.nih.gov/pubmed/29855128 http://dx.doi.org/10.1002/acm2.12360 |
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author | Poder, Joel Cutajar, Dean Guatelli, Susanna Petasecca, Marco Howie, Andrew Bucci, Joseph Rosenfeld, Anatoly |
author_facet | Poder, Joel Cutajar, Dean Guatelli, Susanna Petasecca, Marco Howie, Andrew Bucci, Joseph Rosenfeld, Anatoly |
author_sort | Poder, Joel |
collection | PubMed |
description | PURPOSE: This study aims to assess the accuracy of source position verification during high‐dose rate (HDR) prostate brachytherapy using a novel, in‐house developed two‐dimensional (2D) diode array (the Magic Plate), embedded exactly below the patient within a carbon fiber couch. The effect of tissue inhomogeneities on source localization accuracy is examined. METHOD: Monte Carlo (MC) simulations of 12 source positions from a HDR prostate brachytherapy treatment were performed using the Geant4 toolkit. An Ir‐192 Flexisource (Isodose Control, Veenendaal, the Netherlands) was simulated inside a voxelized patient geometry, and the dose deposited in each detector of the Magic Plate evaluated. The dose deposited in each detector was then used to localize the source position using a proprietary reconstruction algorithm. RESULTS: The accuracy of source position verification using the Magic Plate embedded in the patient couch was found to be affected by the tissue inhomogeneities within the patient, with an average difference of 2.1 ± 0.8 mm (k = 1) between the Magic Plate predicted and known source positions. Recalculation of the simulations with all voxels assigned a density of water improved this verification accuracy to within 1 mm. CONCLUSION: Source position verification using the Magic Plate during a HDR prostate brachytherapy treatment was examined using MC simulations. In a homogenous geometry (water), the Magic Plate was able to localize the source to within 1 mm, however, the verification accuracy was negatively affected by inhomogeneities; this can be corrected for by using density information obtained from CT, making the proposed tool attractive for use as a real‐time in vivo quality assurance (QA) device in HDR brachytherapy for prostate cancer. |
format | Online Article Text |
id | pubmed-6036394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60363942018-07-12 HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study Poder, Joel Cutajar, Dean Guatelli, Susanna Petasecca, Marco Howie, Andrew Bucci, Joseph Rosenfeld, Anatoly J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: This study aims to assess the accuracy of source position verification during high‐dose rate (HDR) prostate brachytherapy using a novel, in‐house developed two‐dimensional (2D) diode array (the Magic Plate), embedded exactly below the patient within a carbon fiber couch. The effect of tissue inhomogeneities on source localization accuracy is examined. METHOD: Monte Carlo (MC) simulations of 12 source positions from a HDR prostate brachytherapy treatment were performed using the Geant4 toolkit. An Ir‐192 Flexisource (Isodose Control, Veenendaal, the Netherlands) was simulated inside a voxelized patient geometry, and the dose deposited in each detector of the Magic Plate evaluated. The dose deposited in each detector was then used to localize the source position using a proprietary reconstruction algorithm. RESULTS: The accuracy of source position verification using the Magic Plate embedded in the patient couch was found to be affected by the tissue inhomogeneities within the patient, with an average difference of 2.1 ± 0.8 mm (k = 1) between the Magic Plate predicted and known source positions. Recalculation of the simulations with all voxels assigned a density of water improved this verification accuracy to within 1 mm. CONCLUSION: Source position verification using the Magic Plate during a HDR prostate brachytherapy treatment was examined using MC simulations. In a homogenous geometry (water), the Magic Plate was able to localize the source to within 1 mm, however, the verification accuracy was negatively affected by inhomogeneities; this can be corrected for by using density information obtained from CT, making the proposed tool attractive for use as a real‐time in vivo quality assurance (QA) device in HDR brachytherapy for prostate cancer. John Wiley and Sons Inc. 2018-06-01 /pmc/articles/PMC6036394/ /pubmed/29855128 http://dx.doi.org/10.1002/acm2.12360 Text en © 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Oncology Physics Poder, Joel Cutajar, Dean Guatelli, Susanna Petasecca, Marco Howie, Andrew Bucci, Joseph Rosenfeld, Anatoly HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study |
title |
HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study |
title_full |
HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study |
title_fullStr |
HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study |
title_full_unstemmed |
HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study |
title_short |
HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study |
title_sort | hdr brachytherapy in vivo source position verification using a 2d diode array: a monte carlo study |
topic | Radiation Oncology Physics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036394/ https://www.ncbi.nlm.nih.gov/pubmed/29855128 http://dx.doi.org/10.1002/acm2.12360 |
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