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HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study

PURPOSE: This study aims to assess the accuracy of source position verification during high‐dose rate (HDR) prostate brachytherapy using a novel, in‐house developed two‐dimensional (2D) diode array (the Magic Plate), embedded exactly below the patient within a carbon fiber couch. The effect of tissu...

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Autores principales: Poder, Joel, Cutajar, Dean, Guatelli, Susanna, Petasecca, Marco, Howie, Andrew, Bucci, Joseph, Rosenfeld, Anatoly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036394/
https://www.ncbi.nlm.nih.gov/pubmed/29855128
http://dx.doi.org/10.1002/acm2.12360
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author Poder, Joel
Cutajar, Dean
Guatelli, Susanna
Petasecca, Marco
Howie, Andrew
Bucci, Joseph
Rosenfeld, Anatoly
author_facet Poder, Joel
Cutajar, Dean
Guatelli, Susanna
Petasecca, Marco
Howie, Andrew
Bucci, Joseph
Rosenfeld, Anatoly
author_sort Poder, Joel
collection PubMed
description PURPOSE: This study aims to assess the accuracy of source position verification during high‐dose rate (HDR) prostate brachytherapy using a novel, in‐house developed two‐dimensional (2D) diode array (the Magic Plate), embedded exactly below the patient within a carbon fiber couch. The effect of tissue inhomogeneities on source localization accuracy is examined. METHOD: Monte Carlo (MC) simulations of 12 source positions from a HDR prostate brachytherapy treatment were performed using the Geant4 toolkit. An Ir‐192 Flexisource (Isodose Control, Veenendaal, the Netherlands) was simulated inside a voxelized patient geometry, and the dose deposited in each detector of the Magic Plate evaluated. The dose deposited in each detector was then used to localize the source position using a proprietary reconstruction algorithm. RESULTS: The accuracy of source position verification using the Magic Plate embedded in the patient couch was found to be affected by the tissue inhomogeneities within the patient, with an average difference of 2.1 ± 0.8 mm (k = 1) between the Magic Plate predicted and known source positions. Recalculation of the simulations with all voxels assigned a density of water improved this verification accuracy to within 1 mm. CONCLUSION: Source position verification using the Magic Plate during a HDR prostate brachytherapy treatment was examined using MC simulations. In a homogenous geometry (water), the Magic Plate was able to localize the source to within 1 mm, however, the verification accuracy was negatively affected by inhomogeneities; this can be corrected for by using density information obtained from CT, making the proposed tool attractive for use as a real‐time in vivo quality assurance (QA) device in HDR brachytherapy for prostate cancer.
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spelling pubmed-60363942018-07-12 HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study Poder, Joel Cutajar, Dean Guatelli, Susanna Petasecca, Marco Howie, Andrew Bucci, Joseph Rosenfeld, Anatoly J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: This study aims to assess the accuracy of source position verification during high‐dose rate (HDR) prostate brachytherapy using a novel, in‐house developed two‐dimensional (2D) diode array (the Magic Plate), embedded exactly below the patient within a carbon fiber couch. The effect of tissue inhomogeneities on source localization accuracy is examined. METHOD: Monte Carlo (MC) simulations of 12 source positions from a HDR prostate brachytherapy treatment were performed using the Geant4 toolkit. An Ir‐192 Flexisource (Isodose Control, Veenendaal, the Netherlands) was simulated inside a voxelized patient geometry, and the dose deposited in each detector of the Magic Plate evaluated. The dose deposited in each detector was then used to localize the source position using a proprietary reconstruction algorithm. RESULTS: The accuracy of source position verification using the Magic Plate embedded in the patient couch was found to be affected by the tissue inhomogeneities within the patient, with an average difference of 2.1 ± 0.8 mm (k = 1) between the Magic Plate predicted and known source positions. Recalculation of the simulations with all voxels assigned a density of water improved this verification accuracy to within 1 mm. CONCLUSION: Source position verification using the Magic Plate during a HDR prostate brachytherapy treatment was examined using MC simulations. In a homogenous geometry (water), the Magic Plate was able to localize the source to within 1 mm, however, the verification accuracy was negatively affected by inhomogeneities; this can be corrected for by using density information obtained from CT, making the proposed tool attractive for use as a real‐time in vivo quality assurance (QA) device in HDR brachytherapy for prostate cancer. John Wiley and Sons Inc. 2018-06-01 /pmc/articles/PMC6036394/ /pubmed/29855128 http://dx.doi.org/10.1002/acm2.12360 Text en © 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Poder, Joel
Cutajar, Dean
Guatelli, Susanna
Petasecca, Marco
Howie, Andrew
Bucci, Joseph
Rosenfeld, Anatoly
HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study
title HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study
title_full HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study
title_fullStr HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study
title_full_unstemmed HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study
title_short HDR brachytherapy in vivo source position verification using a 2D diode array: A Monte Carlo study
title_sort hdr brachytherapy in vivo source position verification using a 2d diode array: a monte carlo study
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036394/
https://www.ncbi.nlm.nih.gov/pubmed/29855128
http://dx.doi.org/10.1002/acm2.12360
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