miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7

The aim of this study was to investigate whether the miR-184 could regulate the proliferation of the tongue squamous cell carcinoma (TSCC) through sex-determining region Y-box 7 (SOX7) gene. miR-184 expression was upregulated in TSCC cell lines and tissues. MTT assay revealed that overexpression of...

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Detalles Bibliográficos
Autores principales: Chen, Daiyun, Li, Junfu, Li, Shunrong, Han, Ping, Li, Ning, Wang, Yi, Du, Shouqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036414/
https://www.ncbi.nlm.nih.gov/pubmed/30008922
http://dx.doi.org/10.3892/ol.2018.8906
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author Chen, Daiyun
Li, Junfu
Li, Shunrong
Han, Ping
Li, Ning
Wang, Yi
Du, Shouqin
author_facet Chen, Daiyun
Li, Junfu
Li, Shunrong
Han, Ping
Li, Ning
Wang, Yi
Du, Shouqin
author_sort Chen, Daiyun
collection PubMed
description The aim of this study was to investigate whether the miR-184 could regulate the proliferation of the tongue squamous cell carcinoma (TSCC) through sex-determining region Y-box 7 (SOX7) gene. miR-184 expression was upregulated in TSCC cell lines and tissues. MTT assay revealed that overexpression of miR-184 significantly promoted the proliferation of the TSCC cells in vitro. SOX7 was the direct target of miR-184 and luciferase reporter assay confirmed that miR-184 downregulated the expression of SOX7. MTT assay verified that knockdown of SOX7 remarkably promoted the proliferation of TSCC cells in vitro. miR-184 promoted the proliferation of TSCC by targeting SOX7. Taken together, our results provided a new potential therapeutic target for TSCC treatment.
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spelling pubmed-60364142018-07-15 miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7 Chen, Daiyun Li, Junfu Li, Shunrong Han, Ping Li, Ning Wang, Yi Du, Shouqin Oncol Lett Articles The aim of this study was to investigate whether the miR-184 could regulate the proliferation of the tongue squamous cell carcinoma (TSCC) through sex-determining region Y-box 7 (SOX7) gene. miR-184 expression was upregulated in TSCC cell lines and tissues. MTT assay revealed that overexpression of miR-184 significantly promoted the proliferation of the TSCC cells in vitro. SOX7 was the direct target of miR-184 and luciferase reporter assay confirmed that miR-184 downregulated the expression of SOX7. MTT assay verified that knockdown of SOX7 remarkably promoted the proliferation of TSCC cells in vitro. miR-184 promoted the proliferation of TSCC by targeting SOX7. Taken together, our results provided a new potential therapeutic target for TSCC treatment. D.A. Spandidos 2018-08 2018-06-05 /pmc/articles/PMC6036414/ /pubmed/30008922 http://dx.doi.org/10.3892/ol.2018.8906 Text en Copyright: © Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Chen, Daiyun
Li, Junfu
Li, Shunrong
Han, Ping
Li, Ning
Wang, Yi
Du, Shouqin
miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7
title miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7
title_full miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7
title_fullStr miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7
title_full_unstemmed miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7
title_short miR-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting SOX7
title_sort mir-184 promotes cell proliferation in tongue squamous cell carcinoma by targeting sox7
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036414/
https://www.ncbi.nlm.nih.gov/pubmed/30008922
http://dx.doi.org/10.3892/ol.2018.8906
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