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Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR-96 in serum

Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013...

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Autores principales: Xu, Yongyun, Wang, Zhenfang, Bi, Yangang, Duan, Zuyun, Yue, Xuewang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036421/
https://www.ncbi.nlm.nih.gov/pubmed/30008900
http://dx.doi.org/10.3892/ol.2018.8863
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author Xu, Yongyun
Wang, Zhenfang
Bi, Yangang
Duan, Zuyun
Yue, Xuewang
author_facet Xu, Yongyun
Wang, Zhenfang
Bi, Yangang
Duan, Zuyun
Yue, Xuewang
author_sort Xu, Yongyun
collection PubMed
description Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two groups of patients underwent CT examination, and the signs and symptoms were recorded. The expression of miR-96 in the serum of the two groups was detected by RT-PCR, and the correlation between the expression of serum miR-96 and CT features was analyzed. In patients with adrenocortical tumor, serum miR-96 expression levels were significantly higher in patients with tumor diameter ≥5 cm than those with tumor diameter <5 cm (p<0.001). In patients with adrenal medullary tumor, serum miR-96 expression levels were significantly higher in patients with tumor diameter ≥3 cm than those with tumor diameter <3 cm (p<0.001). In patients with adrenocortical or adrenal medullary tumor, serum miR-96 expression levels were significantly higher in patients with peripheral infiltration than those without peripheral infiltration (p<0.001), and serum miR-96 expression levels were also significantly higher in patients with distant metastasis than those without distant metastasis (p<0.001). Serum levels of miR-96 in patients with benign adrenocortical and adrenal medullary tumors were significantly lower than those with malignant tumors in the same group (p<0.001). miR-96 may have oncogenic functions in patients with adrenocortical or adrenal medullary tumors. Increased expression level of miR-96 may promote proliferation, invasion and metastasis of tumors, and serum levels of miR-96 provide references for the diagnosis of adrenocortical and adrenal medullary tumors.
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spelling pubmed-60364212018-07-15 Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR-96 in serum Xu, Yongyun Wang, Zhenfang Bi, Yangang Duan, Zuyun Yue, Xuewang Oncol Lett Articles Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two groups of patients underwent CT examination, and the signs and symptoms were recorded. The expression of miR-96 in the serum of the two groups was detected by RT-PCR, and the correlation between the expression of serum miR-96 and CT features was analyzed. In patients with adrenocortical tumor, serum miR-96 expression levels were significantly higher in patients with tumor diameter ≥5 cm than those with tumor diameter <5 cm (p<0.001). In patients with adrenal medullary tumor, serum miR-96 expression levels were significantly higher in patients with tumor diameter ≥3 cm than those with tumor diameter <3 cm (p<0.001). In patients with adrenocortical or adrenal medullary tumor, serum miR-96 expression levels were significantly higher in patients with peripheral infiltration than those without peripheral infiltration (p<0.001), and serum miR-96 expression levels were also significantly higher in patients with distant metastasis than those without distant metastasis (p<0.001). Serum levels of miR-96 in patients with benign adrenocortical and adrenal medullary tumors were significantly lower than those with malignant tumors in the same group (p<0.001). miR-96 may have oncogenic functions in patients with adrenocortical or adrenal medullary tumors. Increased expression level of miR-96 may promote proliferation, invasion and metastasis of tumors, and serum levels of miR-96 provide references for the diagnosis of adrenocortical and adrenal medullary tumors. D.A. Spandidos 2018-08 2018-05-31 /pmc/articles/PMC6036421/ /pubmed/30008900 http://dx.doi.org/10.3892/ol.2018.8863 Text en Copyright: © Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Xu, Yongyun
Wang, Zhenfang
Bi, Yangang
Duan, Zuyun
Yue, Xuewang
Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR-96 in serum
title Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR-96 in serum
title_full Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR-96 in serum
title_fullStr Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR-96 in serum
title_full_unstemmed Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR-96 in serum
title_short Correlation between CT features of adrenocortical and adrenal medullary tumors and expression of miR-96 in serum
title_sort correlation between ct features of adrenocortical and adrenal medullary tumors and expression of mir-96 in serum
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036421/
https://www.ncbi.nlm.nih.gov/pubmed/30008900
http://dx.doi.org/10.3892/ol.2018.8863
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