Cargando…

Decreased BMP-7 and p-Smad1/5/8 expression, and increased levels of gremlin in hepatocellular carcinoma

The aim of the present study was to investigate the expression of bone morphogenetic protein-7 (BMP-7), gremlin, and p-Smad/1/5/8 in carcinomatous and para-carcinoma tissue specimens from patients with hepatocellular carcinoma (HCC). The association of serum BMP-7 levels with clinicopathological par...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Lina, Ding, Qin, Zhao, Li, Pan, Yu, Song, Zhengxia, Qin, Yanan, Yan, Xuebing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036485/ https://www.ncbi.nlm.nih.gov/pubmed/30008908 http://dx.doi.org/10.3892/ol.2018.8918

Ejemplares similares

Saikosaponin D Inhibits Peritoneal Fibrosis in Rats With Renal Failure by Regulation of TGFβ1/ BMP7 / Gremlin1/ Smad Pathway
por: Ruiqi, Liu, et al.
Publicado: (2021)

Gremlin-2 is a BMP antagonist that is regulated by the circadian clock
por: Yeung, Ching-Yan Chloé, et al.
Publicado: (2014)

Structure of Gremlin-1 and analysis of its interaction with BMP-2
por: Kišonaitė, Miglė, et al.
Publicado: (2016)

Gremlin-1 suppression increases BMP-2-induced osteogenesis of human mesenchymal stem cells
por: Hu, Kongzu, et al.
Publicado: (2017)

Gremlin in the Vitreous of Patients with Proliferative Diabetic Retinopathy and the Downregulation of Gremlin in Retinal Pigment Epithelial Cells
por: Qin, Dong, et al.
Publicado: (2020)

Gremlin-1 Induces BMP-Independent Tumor Cell Proliferation, Migration, and Invasion
por: Kim, Minsoo, et al.
Publicado: (2012)

BMP-7 suppresses excessive scar formation by activating the BMP-7/Smad1/5/8 signaling pathway
por: Guo, Jingdong, et al.
Publicado: (2017)

Gremlin 1 — small protein, big impact: the multiorgan consequences of disrupted BMP antagonism(†)
por: Gooding, Sarah, et al.
Publicado: (2020)

Gremlins : ¡ya estamos aquí!
por: Spielberg, Steven, 1946-

Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells
por: Rodrigues-Diez, Raquel, et al.
Publicado: (2014)

Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin
por: Frank, Natasha Y., et al.
Publicado: (2006)

Gremlin-1 and BMP-4 Overexpressed in Osteoarthritis Drive an Osteochondral-Remodeling Program in Osteoblasts and Hypertrophic Chondrocytes
por: Pérez-Lozano, Maria-Luisa, et al.
Publicado: (2022)

The BMP antagonist gremlin 1 contributes to the development of cortical excitatory neurons, motor balance and fear responses
por: Ichinose, Mari, et al.
Publicado: (2021)

BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH
por: Baboota, Ritesh K., et al.
Publicado: (2022)

Analysis of Gremlin 1 Levels Following Sleeve Gastrectomy
por: Alregaiey, Khalid A, et al.
Publicado: (2023)

GREMLIN2 and atrial fibrillation
Publicado: (2013)

Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles
por: Niiyama, Shiro, et al.
Publicado: (2022)

CD44 modulates Smad1 activation in the BMP-7 signaling pathway
por: Peterson, Richard S., et al.
Publicado: (2004)

Gremlin-1: An endogenous BMP antagonist induces epithelial-mesenchymal transition and interferes with redifferentiation in fetal RPE cells with repeated wounds
por: Li, Duo, et al.
Publicado: (2019)

Gremlin Enhances the Determined Path to Cardiomyogenesis
por: Kami, Daisuke, et al.
Publicado: (2008)

Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver
por: Khatib Shahidi, Roxana, et al.
Publicado: (2021)

Increased BMP-Smad signaling does not affect net bone mass in long bones
por: Omi, Maiko, et al.
Publicado: (2023)

ActRIIA and BMPRII Type II BMP Receptor Subunits Selectively Required for Smad4-Independent BMP7-Evoked Chemotaxis
por: Perron, Jeanette C., et al.
Publicado: (2009)

Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds
por: Zuniga, Aimée, et al.
Publicado: (2012)

Transcription factor GATA2 may potentiate follicle-stimulating hormone production in mice via induction of the BMP antagonist gremlin in gonadotrope cells
por: Schang, Gauthier, et al.
Publicado: (2022)

Overexpression of Gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression
por: Yu, Yongtian, et al.
Publicado: (2018)

Gremlin is Overexpressed in Lung Adenocarcinoma and Increases Cell Growth and Proliferation in Normal Lung Cells
por: Mulvihill, Michael S., et al.
Publicado: (2012)

Induction of Olig2(+) Precursors by FGF Involves BMP Signalling Blockade at the Smad Level
por: Bilican, Bilada, et al.
Publicado: (2008)

Wedelolactone Enhances Osteoblastogenesis through ERK- and JNK-mediated BMP2 Expression and Smad/1/5/8 Phosphorylation
por: Zhu, Di, et al.
Publicado: (2018)

Preferential Activation of SMAD1/5/8 on the Fibrosa Endothelium in Calcified Human Aortic Valves - Association with Low BMP Antagonists and SMAD6
por: Ankeny, Randall F., et al.
Publicado: (2011)

Gremlin mediates the TGF-β-induced induction of profibrogenic genes in human retinal pigment epithelial cells
por: Qin, Dong, et al.
Publicado: (2020)

BMP4 Enhances Foam Cell Formation by BMPR-2/Smad1/5/8 Signaling
por: Feng, Jun, et al.
Publicado: (2014)

Gremlin-1 Concentrations Are Correlated with the Severity of Knee Osteoarthritis
por: Yi, Jun, et al.
Publicado: (2016)

Production and Biochemical Characterization of Dimeric Recombinant Gremlin-1
por: Mitola, Stefania, et al.
Publicado: (2022)

Circulating Gremlin-1 is elevated in systemic sclerosis patients
por: O’Reilly, Steven
Publicado: (2021)

Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling
por: Wu, Jian, et al.
Publicado: (2021)

Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma
por: Chiou, Jean, et al.
Publicado: (2017)

Deficiency of Macf1 in osterix expressing cells decreases bone formation by Bmp2/Smad/Runx2 pathway
por: Qiu, Wu‐Xia, et al.
Publicado: (2019)

Gremlin in the pathogenesis of hepatocellular carcinoma complicating chronic hepatitis C: an immunohistochemical and PCR study of human liver biopsies
por: Guimei, Maha, et al.
Publicado: (2012)

Does Smad6 methylation control BMP signaling in cancer?
por: Xu, Jian, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_m37ctmndeqkvlc165eaa048e9f