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The tumor suppressor role of microRNA-338-3p in renal cell carcinoma

Human renal cell carcinoma (RCC) is the most common type of kidney malignancy in adults accounting for 2–3% of all adult malignancies. In China, RCC accounts for ~0.5% of all cancer-associated mortalities, ranking 16th among all cancer types. For early-stage RCC, surgery is the recommended treatment...

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Autores principales: Huang, Yidong, Wu, Yang, Zeng, Li, Shan, Wei, Huang, Lugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036501/
https://www.ncbi.nlm.nih.gov/pubmed/30008918
http://dx.doi.org/10.3892/ol.2018.8914
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author Huang, Yidong
Wu, Yang
Zeng, Li
Shan, Wei
Huang, Lugang
author_facet Huang, Yidong
Wu, Yang
Zeng, Li
Shan, Wei
Huang, Lugang
author_sort Huang, Yidong
collection PubMed
description Human renal cell carcinoma (RCC) is the most common type of kidney malignancy in adults accounting for 2–3% of all adult malignancies. In China, RCC accounts for ~0.5% of all cancer-associated mortalities, ranking 16th among all cancer types. For early-stage RCC, surgery is the recommended treatment. Molecularly targeted therapy is the preferred first-line treatment for clear-cell RCC. However, more potential targets are required. MicroRNA-338-3p (miR-338-3p) functions as a tumor suppressor in various cancers, but has not been studied in RCC. Accordingly, the present study investigated the role of miR-338-3p of RCC. It was demonstrated that miR-338-3p was present at low levels in RCC tissues. Also, overexpression of miR-338-3p inhibited cell proliferation and promoted cell apoptosis, and downregulation of miR-338-3p promoted cell proliferation. The 3′ untranslated region of AKT serine/threonine kinase 3 was targeted by miR-338-3p. In conclusion, the data of the present study revealed the inhibitory function of miR-338-3p in RCC and suggested that miR-338-3p is novel therapeutic target for RCC, but further investigation is needed.
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spelling pubmed-60365012018-07-15 The tumor suppressor role of microRNA-338-3p in renal cell carcinoma Huang, Yidong Wu, Yang Zeng, Li Shan, Wei Huang, Lugang Oncol Lett Articles Human renal cell carcinoma (RCC) is the most common type of kidney malignancy in adults accounting for 2–3% of all adult malignancies. In China, RCC accounts for ~0.5% of all cancer-associated mortalities, ranking 16th among all cancer types. For early-stage RCC, surgery is the recommended treatment. Molecularly targeted therapy is the preferred first-line treatment for clear-cell RCC. However, more potential targets are required. MicroRNA-338-3p (miR-338-3p) functions as a tumor suppressor in various cancers, but has not been studied in RCC. Accordingly, the present study investigated the role of miR-338-3p of RCC. It was demonstrated that miR-338-3p was present at low levels in RCC tissues. Also, overexpression of miR-338-3p inhibited cell proliferation and promoted cell apoptosis, and downregulation of miR-338-3p promoted cell proliferation. The 3′ untranslated region of AKT serine/threonine kinase 3 was targeted by miR-338-3p. In conclusion, the data of the present study revealed the inhibitory function of miR-338-3p in RCC and suggested that miR-338-3p is novel therapeutic target for RCC, but further investigation is needed. D.A. Spandidos 2018-08 2018-06-06 /pmc/articles/PMC6036501/ /pubmed/30008918 http://dx.doi.org/10.3892/ol.2018.8914 Text en Copyright: © Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Huang, Yidong
Wu, Yang
Zeng, Li
Shan, Wei
Huang, Lugang
The tumor suppressor role of microRNA-338-3p in renal cell carcinoma
title The tumor suppressor role of microRNA-338-3p in renal cell carcinoma
title_full The tumor suppressor role of microRNA-338-3p in renal cell carcinoma
title_fullStr The tumor suppressor role of microRNA-338-3p in renal cell carcinoma
title_full_unstemmed The tumor suppressor role of microRNA-338-3p in renal cell carcinoma
title_short The tumor suppressor role of microRNA-338-3p in renal cell carcinoma
title_sort tumor suppressor role of microrna-338-3p in renal cell carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036501/
https://www.ncbi.nlm.nih.gov/pubmed/30008918
http://dx.doi.org/10.3892/ol.2018.8914
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