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The tumor suppressor role of microRNA-338-3p in renal cell carcinoma
Human renal cell carcinoma (RCC) is the most common type of kidney malignancy in adults accounting for 2–3% of all adult malignancies. In China, RCC accounts for ~0.5% of all cancer-associated mortalities, ranking 16th among all cancer types. For early-stage RCC, surgery is the recommended treatment...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036501/ https://www.ncbi.nlm.nih.gov/pubmed/30008918 http://dx.doi.org/10.3892/ol.2018.8914 |
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author | Huang, Yidong Wu, Yang Zeng, Li Shan, Wei Huang, Lugang |
author_facet | Huang, Yidong Wu, Yang Zeng, Li Shan, Wei Huang, Lugang |
author_sort | Huang, Yidong |
collection | PubMed |
description | Human renal cell carcinoma (RCC) is the most common type of kidney malignancy in adults accounting for 2–3% of all adult malignancies. In China, RCC accounts for ~0.5% of all cancer-associated mortalities, ranking 16th among all cancer types. For early-stage RCC, surgery is the recommended treatment. Molecularly targeted therapy is the preferred first-line treatment for clear-cell RCC. However, more potential targets are required. MicroRNA-338-3p (miR-338-3p) functions as a tumor suppressor in various cancers, but has not been studied in RCC. Accordingly, the present study investigated the role of miR-338-3p of RCC. It was demonstrated that miR-338-3p was present at low levels in RCC tissues. Also, overexpression of miR-338-3p inhibited cell proliferation and promoted cell apoptosis, and downregulation of miR-338-3p promoted cell proliferation. The 3′ untranslated region of AKT serine/threonine kinase 3 was targeted by miR-338-3p. In conclusion, the data of the present study revealed the inhibitory function of miR-338-3p in RCC and suggested that miR-338-3p is novel therapeutic target for RCC, but further investigation is needed. |
format | Online Article Text |
id | pubmed-6036501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-60365012018-07-15 The tumor suppressor role of microRNA-338-3p in renal cell carcinoma Huang, Yidong Wu, Yang Zeng, Li Shan, Wei Huang, Lugang Oncol Lett Articles Human renal cell carcinoma (RCC) is the most common type of kidney malignancy in adults accounting for 2–3% of all adult malignancies. In China, RCC accounts for ~0.5% of all cancer-associated mortalities, ranking 16th among all cancer types. For early-stage RCC, surgery is the recommended treatment. Molecularly targeted therapy is the preferred first-line treatment for clear-cell RCC. However, more potential targets are required. MicroRNA-338-3p (miR-338-3p) functions as a tumor suppressor in various cancers, but has not been studied in RCC. Accordingly, the present study investigated the role of miR-338-3p of RCC. It was demonstrated that miR-338-3p was present at low levels in RCC tissues. Also, overexpression of miR-338-3p inhibited cell proliferation and promoted cell apoptosis, and downregulation of miR-338-3p promoted cell proliferation. The 3′ untranslated region of AKT serine/threonine kinase 3 was targeted by miR-338-3p. In conclusion, the data of the present study revealed the inhibitory function of miR-338-3p in RCC and suggested that miR-338-3p is novel therapeutic target for RCC, but further investigation is needed. D.A. Spandidos 2018-08 2018-06-06 /pmc/articles/PMC6036501/ /pubmed/30008918 http://dx.doi.org/10.3892/ol.2018.8914 Text en Copyright: © Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Huang, Yidong Wu, Yang Zeng, Li Shan, Wei Huang, Lugang The tumor suppressor role of microRNA-338-3p in renal cell carcinoma |
title | The tumor suppressor role of microRNA-338-3p in renal cell carcinoma |
title_full | The tumor suppressor role of microRNA-338-3p in renal cell carcinoma |
title_fullStr | The tumor suppressor role of microRNA-338-3p in renal cell carcinoma |
title_full_unstemmed | The tumor suppressor role of microRNA-338-3p in renal cell carcinoma |
title_short | The tumor suppressor role of microRNA-338-3p in renal cell carcinoma |
title_sort | tumor suppressor role of microrna-338-3p in renal cell carcinoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036501/ https://www.ncbi.nlm.nih.gov/pubmed/30008918 http://dx.doi.org/10.3892/ol.2018.8914 |
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