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Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway
The inhibitory effect of resveratrol on the growth of gastric cancer cells through downregulation of the Wnt/β-catenin signaling pathway were studied. First we determined the effective concentration of resveratrol on the growth and proliferation of MGC-803 gastric cancer cells. Methylthiazolyl tetra...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036503/ https://www.ncbi.nlm.nih.gov/pubmed/30008840 http://dx.doi.org/10.3892/ol.2018.8772 |
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author | Dai, Hui Deng, Hou-Bo Wang, Ya-Hong Guo, Jia-Juan |
author_facet | Dai, Hui Deng, Hou-Bo Wang, Ya-Hong Guo, Jia-Juan |
author_sort | Dai, Hui |
collection | PubMed |
description | The inhibitory effect of resveratrol on the growth of gastric cancer cells through downregulation of the Wnt/β-catenin signaling pathway were studied. First we determined the effective concentration of resveratrol on the growth and proliferation of MGC-803 gastric cancer cells. Methylthiazolyl tetrazolium assay showed that resveratrol significantly inhibited the proliferation of MGC-803 cells in a dose-dependent manner. Resveratrol induced apoptotic morphological changes in MGC-803 cells. Reverse transcription-polymerase chain reaction and western blot analysis showed that resveratrol downregulated the expression of three important components of the Wnt signaling pathway, β-catenin, c-myc, and cyclin D1, at the mRNA and protein levels. Overall, resveratrol inhibits the growth of MGC-803 cells by inhibiting the Wnt signaling pathway. This study provides a new idea and direction for the antitumor mechanism of resveratrol. |
format | Online Article Text |
id | pubmed-6036503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-60365032018-07-15 Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway Dai, Hui Deng, Hou-Bo Wang, Ya-Hong Guo, Jia-Juan Oncol Lett Articles The inhibitory effect of resveratrol on the growth of gastric cancer cells through downregulation of the Wnt/β-catenin signaling pathway were studied. First we determined the effective concentration of resveratrol on the growth and proliferation of MGC-803 gastric cancer cells. Methylthiazolyl tetrazolium assay showed that resveratrol significantly inhibited the proliferation of MGC-803 cells in a dose-dependent manner. Resveratrol induced apoptotic morphological changes in MGC-803 cells. Reverse transcription-polymerase chain reaction and western blot analysis showed that resveratrol downregulated the expression of three important components of the Wnt signaling pathway, β-catenin, c-myc, and cyclin D1, at the mRNA and protein levels. Overall, resveratrol inhibits the growth of MGC-803 cells by inhibiting the Wnt signaling pathway. This study provides a new idea and direction for the antitumor mechanism of resveratrol. D.A. Spandidos 2018-08 2018-05-22 /pmc/articles/PMC6036503/ /pubmed/30008840 http://dx.doi.org/10.3892/ol.2018.8772 Text en Copyright: © Dai et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Dai, Hui Deng, Hou-Bo Wang, Ya-Hong Guo, Jia-Juan Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway |
title | Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway |
title_full | Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway |
title_fullStr | Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway |
title_full_unstemmed | Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway |
title_short | Resveratrol inhibits the growth of gastric cancer via the Wnt/β-catenin pathway |
title_sort | resveratrol inhibits the growth of gastric cancer via the wnt/β-catenin pathway |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036503/ https://www.ncbi.nlm.nih.gov/pubmed/30008840 http://dx.doi.org/10.3892/ol.2018.8772 |
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