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Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells
Gastric cancer is a prevalent, malignant tumor that frequently escapes treatment. Histidine triad nucleotide-binding protein 1 (Hint1) is a haploinsufficient tumor suppressor gene which contributes to intercellular communication, helps to regulate cell proliferation and survival, and is frequently u...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036515/ https://www.ncbi.nlm.nih.gov/pubmed/30008911 http://dx.doi.org/10.3892/ol.2018.8900 |
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author | Wei, Xiaowei Zhou, Jin Hong, Lingzhi Xu, Zhi Zhao, Huanyu Wu, Xiaomin Chen, Jinfei |
author_facet | Wei, Xiaowei Zhou, Jin Hong, Lingzhi Xu, Zhi Zhao, Huanyu Wu, Xiaomin Chen, Jinfei |
author_sort | Wei, Xiaowei |
collection | PubMed |
description | Gastric cancer is a prevalent, malignant tumor that frequently escapes treatment. Histidine triad nucleotide-binding protein 1 (Hint1) is a haploinsufficient tumor suppressor gene which contributes to intercellular communication, helps to regulate cell proliferation and survival, and is frequently underexpressed in gastric cancer. To examine the involvement of Hint1 in gastric cancer, small interfering RNA was used to knock down Hint1 expression in the human gastric cancer cell line SGC-7901. The data revealed that Hint1 inhibited cell proliferation, reduced radiation-induced DNA damage repair and caused G1 phase arrest, which increased the radiosensitivity of gastric cancer cells. Further mechanistic studies revealed a novel function of Hint1, whereby it acted as a negative regulator of extracellular signal-regulated kinase. These results demonstrated the critical function of Hint1 in the biology of human gastric cancer. Acting as a tumor growth suppressor and a radiosensitive agent, this protein is a potential biomarker and may be an attractive target for specific therapeutic interventions against gastric cancer. |
format | Online Article Text |
id | pubmed-6036515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-60365152018-07-15 Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells Wei, Xiaowei Zhou, Jin Hong, Lingzhi Xu, Zhi Zhao, Huanyu Wu, Xiaomin Chen, Jinfei Oncol Lett Articles Gastric cancer is a prevalent, malignant tumor that frequently escapes treatment. Histidine triad nucleotide-binding protein 1 (Hint1) is a haploinsufficient tumor suppressor gene which contributes to intercellular communication, helps to regulate cell proliferation and survival, and is frequently underexpressed in gastric cancer. To examine the involvement of Hint1 in gastric cancer, small interfering RNA was used to knock down Hint1 expression in the human gastric cancer cell line SGC-7901. The data revealed that Hint1 inhibited cell proliferation, reduced radiation-induced DNA damage repair and caused G1 phase arrest, which increased the radiosensitivity of gastric cancer cells. Further mechanistic studies revealed a novel function of Hint1, whereby it acted as a negative regulator of extracellular signal-regulated kinase. These results demonstrated the critical function of Hint1 in the biology of human gastric cancer. Acting as a tumor growth suppressor and a radiosensitive agent, this protein is a potential biomarker and may be an attractive target for specific therapeutic interventions against gastric cancer. D.A. Spandidos 2018-08 2018-06-05 /pmc/articles/PMC6036515/ /pubmed/30008911 http://dx.doi.org/10.3892/ol.2018.8900 Text en Copyright: © Wei et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Wei, Xiaowei Zhou, Jin Hong, Lingzhi Xu, Zhi Zhao, Huanyu Wu, Xiaomin Chen, Jinfei Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells |
title | Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells |
title_full | Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells |
title_fullStr | Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells |
title_full_unstemmed | Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells |
title_short | Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells |
title_sort | hint1 expression inhibits proliferation and promotes radiosensitivity of human sgc7901 gastric cancer cells |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036515/ https://www.ncbi.nlm.nih.gov/pubmed/30008911 http://dx.doi.org/10.3892/ol.2018.8900 |
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