Systemic Fibrinolytic Therapy in the Presence of Absolute Contraindication; a Case Series

In massive pulmonary embolism (PE), fibrinolytic therapy is a potential lifesaving treatment; therefore, if other treatments are not available, the physicians encounter this question: can we accept the risk of complications from fibrinolytic therapy, especially intracranial hemorrhage, in the presen...

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Autores principales: Pishgahi, Mahdi, Alirezaei, Toktam, Hajimoradi, Behzad, Nekooghadam, S. Mojtaba, Shahi, Shima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shahid Beheshti University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036529/
https://www.ncbi.nlm.nih.gov/pubmed/30009227
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author Pishgahi, Mahdi
Alirezaei, Toktam
Hajimoradi, Behzad
Nekooghadam, S. Mojtaba
Shahi, Shima
author_facet Pishgahi, Mahdi
Alirezaei, Toktam
Hajimoradi, Behzad
Nekooghadam, S. Mojtaba
Shahi, Shima
author_sort Pishgahi, Mahdi
collection PubMed
description In massive pulmonary embolism (PE), fibrinolytic therapy is a potential lifesaving treatment; therefore, if other treatments are not available, the physicians encounter this question: can we accept the risk of complications from fibrinolytic therapy, especially intracranial hemorrhage, in the presence of absolute contraindication, in order to save the patient’s life? Here, we describe three cases of massive PE with absolute contraindication for fibrinolytic therapy who presented to emergency department following dyspnea. Since, surgical or catheter embolectomy were not available and patients were very high risk for transferring to another hospital, systemic fibrinolytic was administered. The patients improved clinically and were discharged from hospital. It seems that, if no other acceptable treatments are available, physicians could consider fibrinolytic therapy, even at the presence of contraindication, to save the patient’s life.
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spelling pubmed-60365292018-07-13 Systemic Fibrinolytic Therapy in the Presence of Absolute Contraindication; a Case Series Pishgahi, Mahdi Alirezaei, Toktam Hajimoradi, Behzad Nekooghadam, S. Mojtaba Shahi, Shima Emerg (Tehran) Case Report In massive pulmonary embolism (PE), fibrinolytic therapy is a potential lifesaving treatment; therefore, if other treatments are not available, the physicians encounter this question: can we accept the risk of complications from fibrinolytic therapy, especially intracranial hemorrhage, in the presence of absolute contraindication, in order to save the patient’s life? Here, we describe three cases of massive PE with absolute contraindication for fibrinolytic therapy who presented to emergency department following dyspnea. Since, surgical or catheter embolectomy were not available and patients were very high risk for transferring to another hospital, systemic fibrinolytic was administered. The patients improved clinically and were discharged from hospital. It seems that, if no other acceptable treatments are available, physicians could consider fibrinolytic therapy, even at the presence of contraindication, to save the patient’s life. Shahid Beheshti University of Medical Sciences 2018 2018-04-22 /pmc/articles/PMC6036529/ /pubmed/30009227 Text en Copyright (2018) Shahid Beheshti University ofMedical Sciences This open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0)(https://creativecommons.org/licenses/by-nc/3.0/).
spellingShingle Case Report
Pishgahi, Mahdi
Alirezaei, Toktam
Hajimoradi, Behzad
Nekooghadam, S. Mojtaba
Shahi, Shima
Systemic Fibrinolytic Therapy in the Presence of Absolute Contraindication; a Case Series
title Systemic Fibrinolytic Therapy in the Presence of Absolute Contraindication; a Case Series
title_full Systemic Fibrinolytic Therapy in the Presence of Absolute Contraindication; a Case Series
title_fullStr Systemic Fibrinolytic Therapy in the Presence of Absolute Contraindication; a Case Series
title_full_unstemmed Systemic Fibrinolytic Therapy in the Presence of Absolute Contraindication; a Case Series
title_short Systemic Fibrinolytic Therapy in the Presence of Absolute Contraindication; a Case Series
title_sort systemic fibrinolytic therapy in the presence of absolute contraindication; a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036529/
https://www.ncbi.nlm.nih.gov/pubmed/30009227
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