A team effort: natural killer cells on the first leg of the tumor immunity relay race

Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells. DC1 dendritic cells subsequently activate CD8+ T cells resulting in effective anti-tum...

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Detalles Bibliográficos
Autores principales: Fessenden, Timothy B., Duong, Ellen, Spranger, Stefani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036670/
https://www.ncbi.nlm.nih.gov/pubmed/29986768
http://dx.doi.org/10.1186/s40425-018-0380-4
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author Fessenden, Timothy B.
Duong, Ellen
Spranger, Stefani
author_facet Fessenden, Timothy B.
Duong, Ellen
Spranger, Stefani
author_sort Fessenden, Timothy B.
collection PubMed
description Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells. DC1 dendritic cells subsequently activate CD8+ T cells resulting in effective anti-tumor immunity. This work highlights the cooperative nature of anti-tumor immunity set in motion by Natural Killer cells, and immune evasion by tumors through their exclusion.
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spelling pubmed-60366702018-07-12 A team effort: natural killer cells on the first leg of the tumor immunity relay race Fessenden, Timothy B. Duong, Ellen Spranger, Stefani J Immunother Cancer Commentary Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells. DC1 dendritic cells subsequently activate CD8+ T cells resulting in effective anti-tumor immunity. This work highlights the cooperative nature of anti-tumor immunity set in motion by Natural Killer cells, and immune evasion by tumors through their exclusion. BioMed Central 2018-07-09 /pmc/articles/PMC6036670/ /pubmed/29986768 http://dx.doi.org/10.1186/s40425-018-0380-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Fessenden, Timothy B.
Duong, Ellen
Spranger, Stefani
A team effort: natural killer cells on the first leg of the tumor immunity relay race
title A team effort: natural killer cells on the first leg of the tumor immunity relay race
title_full A team effort: natural killer cells on the first leg of the tumor immunity relay race
title_fullStr A team effort: natural killer cells on the first leg of the tumor immunity relay race
title_full_unstemmed A team effort: natural killer cells on the first leg of the tumor immunity relay race
title_short A team effort: natural killer cells on the first leg of the tumor immunity relay race
title_sort team effort: natural killer cells on the first leg of the tumor immunity relay race
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036670/
https://www.ncbi.nlm.nih.gov/pubmed/29986768
http://dx.doi.org/10.1186/s40425-018-0380-4
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