Computational Design of Antiangiogenic Peptibody by Fusing Human IgG1 Fc Fragment and HRH Peptide: Structural Modeling, Energetic Analysis, and Dynamics Simulation of Its Binding Potency to VEGF Receptor

Peptibodies represent a new class of biological therapeutics with combination of peptide activity and antibody-like properties. Previously, we discovered a novel peptide HRH that exhibited a dose-dependent angiogenesis-suppressing effect by targeting vascular endothelial growth factor receptors (VEG...

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Detalles Bibliográficos
Autores principales: Ning, Lin, Li, Zhongyan, Bai, Zhengya, Hou, Shasha, He, Bifang, Huang, Jian, Zhou, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036755/
https://www.ncbi.nlm.nih.gov/pubmed/29989101
http://dx.doi.org/10.7150/ijbs.24582

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