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N-Acetylcysteine as an Adjuvant to Letrozole for Induction of Ovulation in Infertile Patients with Polycystic Ovary Syndrome

BACKGROUND: This study was aimed to evaluate the influence of oral N-acetylcysteine (NAC) application as an adjuvant to letrozole on induced ovulation outcomes in patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: This was a placebo-controlled double-blind randomized clinical tri...

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Autores principales: Mostajeran, Fateme, Tehrani, Hatav Ghasemi, Rahbary, Bahare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036781/
https://www.ncbi.nlm.nih.gov/pubmed/30050888
http://dx.doi.org/10.4103/abr.abr_157_17
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author Mostajeran, Fateme
Tehrani, Hatav Ghasemi
Rahbary, Bahare
author_facet Mostajeran, Fateme
Tehrani, Hatav Ghasemi
Rahbary, Bahare
author_sort Mostajeran, Fateme
collection PubMed
description BACKGROUND: This study was aimed to evaluate the influence of oral N-acetylcysteine (NAC) application as an adjuvant to letrozole on induced ovulation outcomes in patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: This was a placebo-controlled double-blind randomized clinical trial with 130 PCOS patients who were infertile. First, patients were randomly divided into two groups. Patients in Group 1 were administered letrozole 5 mg/d plus NAC 1.2 g/d and patients in Group 2 were administered letrozole plus placebo for 5 days starting at the 3(rd) day of the menstruation period. On the 12(th) day of the cycle, ultrasound evaluation was performed, and in whom at least one follicle with an 18–20 mm diameter was found, 10,000 unit human chorionic gonadotropin (hCG) was prescribed, and 36 h after hCG injection, timed intercourse was advised. On the 16(th) day, after hCG injection, serum β-hCG level was evaluated. RESULTS: The number of follicles >18 mm was significantly higher in the letrozole + NAC group (P = 0.007). The ovulation and pregnancy rates were also significantly higher in the letrozole + NAC group (P = 0.045). No adverse side effects and no cases of ovarian hyperstimulation syndrome were observed in NAC group. CONCLUSION: NAC is demonstrated to be a safe and well-tolerated adjuvant to letrozole and can increase the pregnancy rates in PCOS patients.
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spelling pubmed-60367812018-07-26 N-Acetylcysteine as an Adjuvant to Letrozole for Induction of Ovulation in Infertile Patients with Polycystic Ovary Syndrome Mostajeran, Fateme Tehrani, Hatav Ghasemi Rahbary, Bahare Adv Biomed Res Original Article BACKGROUND: This study was aimed to evaluate the influence of oral N-acetylcysteine (NAC) application as an adjuvant to letrozole on induced ovulation outcomes in patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: This was a placebo-controlled double-blind randomized clinical trial with 130 PCOS patients who were infertile. First, patients were randomly divided into two groups. Patients in Group 1 were administered letrozole 5 mg/d plus NAC 1.2 g/d and patients in Group 2 were administered letrozole plus placebo for 5 days starting at the 3(rd) day of the menstruation period. On the 12(th) day of the cycle, ultrasound evaluation was performed, and in whom at least one follicle with an 18–20 mm diameter was found, 10,000 unit human chorionic gonadotropin (hCG) was prescribed, and 36 h after hCG injection, timed intercourse was advised. On the 16(th) day, after hCG injection, serum β-hCG level was evaluated. RESULTS: The number of follicles >18 mm was significantly higher in the letrozole + NAC group (P = 0.007). The ovulation and pregnancy rates were also significantly higher in the letrozole + NAC group (P = 0.045). No adverse side effects and no cases of ovarian hyperstimulation syndrome were observed in NAC group. CONCLUSION: NAC is demonstrated to be a safe and well-tolerated adjuvant to letrozole and can increase the pregnancy rates in PCOS patients. Medknow Publications & Media Pvt Ltd 2018-06-25 /pmc/articles/PMC6036781/ /pubmed/30050888 http://dx.doi.org/10.4103/abr.abr_157_17 Text en Copyright: © 2018 Advanced Biomedical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Mostajeran, Fateme
Tehrani, Hatav Ghasemi
Rahbary, Bahare
N-Acetylcysteine as an Adjuvant to Letrozole for Induction of Ovulation in Infertile Patients with Polycystic Ovary Syndrome
title N-Acetylcysteine as an Adjuvant to Letrozole for Induction of Ovulation in Infertile Patients with Polycystic Ovary Syndrome
title_full N-Acetylcysteine as an Adjuvant to Letrozole for Induction of Ovulation in Infertile Patients with Polycystic Ovary Syndrome
title_fullStr N-Acetylcysteine as an Adjuvant to Letrozole for Induction of Ovulation in Infertile Patients with Polycystic Ovary Syndrome
title_full_unstemmed N-Acetylcysteine as an Adjuvant to Letrozole for Induction of Ovulation in Infertile Patients with Polycystic Ovary Syndrome
title_short N-Acetylcysteine as an Adjuvant to Letrozole for Induction of Ovulation in Infertile Patients with Polycystic Ovary Syndrome
title_sort n-acetylcysteine as an adjuvant to letrozole for induction of ovulation in infertile patients with polycystic ovary syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036781/
https://www.ncbi.nlm.nih.gov/pubmed/30050888
http://dx.doi.org/10.4103/abr.abr_157_17
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