Cargando…

Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages

Sex hormone-binding globulin (SHBG) is a serum protein released mainly by the liver, and a low serum level correlates with a risk for metabolic syndrome including diabetes, obesity, and cardiovascular events. However, the underlying molecular mechanism(s) linking SHBG and metabolic syndrome remains...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamazaki, Hiroki, Kushiyama, Akifumi, Sakoda, Hideyuki, Fujishiro, Midori, Yamamotoya, Takeshi, Nakatsu, Yusuke, Kikuchi, Takako, Kaneko, Sunao, Tanaka, Hirotoshi, Asano, Tomoichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036814/ https://www.ncbi.nlm.nih.gov/pubmed/30046278 http://dx.doi.org/10.1155/2018/3062319

Ejemplares similares

Reduced SHARPIN and LUBAC Formation May Contribute to CCl(4)- or Acetaminophen-Induced Liver Cirrhosis in Mice
por: Yamamotoya, Takeshi, et al.
Publicado: (2017)

Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines
por: Kanna, Machi, et al.
Publicado: (2023)

Gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus
por: Fujishiro, Midori, et al.
Publicado: (2017)

Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications
por: Okubo, Hirofumi, et al.
Publicado: (2018)

Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus
por: Qiang, Shirong, et al.
Publicado: (2015)

Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis
por: Kushiyama, Akifumi, et al.
Publicado: (2016)

Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations
por: Nakatsu, Yusuke, et al.
Publicado: (2016)

Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells
por: Hasei, Shun, et al.
Publicado: (2021)

Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines
por: Kanaoka, Ryuhei, et al.
Publicado: (2015)

Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 Diabetes
por: Fujishiro, Midori, et al.
Publicado: (2021)

Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases
por: Yamamotoya, Takeshi, et al.
Publicado: (2022)

Pathological Role of Pin1 in the Development of DSS-Induced Colitis
por: Matsunaga, Yasuka, et al.
Publicado: (2021)

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins
por: Inoue, Masa-Ki, et al.
Publicado: (2019)

Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells
por: Akasaka, Yasuyuki, et al.
Publicado: (2023)

Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice
por: Mizuno, Yu, et al.
Publicado: (2019)

Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity
por: Yamamotoya, Takeshi, et al.
Publicado: (2017)

High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice
por: Shinjo, Takanori, et al.
Publicado: (2015)

The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model
por: Inoue, Masa-Ki, et al.
Publicado: (2018)

The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice
por: Nakatsu, Yusuke, et al.
Publicado: (2017)

Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation
por: Ueda, Koji, et al.
Publicado: (2019)

Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice
por: Inoue, Masa-Ki, et al.
Publicado: (2019)

Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice
por: Iwashita, Misaki, et al.
Publicado: (2013)

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis
por: Matsunaga, Yasuka, et al.
Publicado: (2015)

Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice
por: Okubo, Hirofumi, et al.
Publicado: (2016)

Lipolytic actions of secretin in mouse adipocytes
por: Sekar, Revathi, et al.
Publicado: (2014)

Roles of peptidyl prolyl isomerase Pin1 in viral propagation
por: Kanna, Machi, et al.
Publicado: (2022)

Insulin and β-adrenergic receptors mediate lipolytic and anti-lipolytic signalling that is not altered by type 2 diabetes in human adipocytes
por: Jönsson, Cecilia, et al.
Publicado: (2019)

Increased 4-Hydroxynonenal Formation Contributes to Obesity-Related Lipolytic Activation in Adipocytes
por: Zhang, Ximei, et al.
Publicado: (2013)

Prolyl isomerase Pin1 plays an essential role in SARS-CoV-2 proliferation, indicating its possibility as a novel therapeutic target
por: Yamamotoya, Takeshi, et al.
Publicado: (2021)

Metabolic Remodeling of Human Skeletal Myocytes by Cocultured Adipocytes Depends on the Lipolytic State of the System
por: Kovalik, Jean-Paul, et al.
Publicado: (2011)

Differentiation of human subcutaneous adipocytes and measurement of lipolytic function induced by GIP or LY3437943
por: Regmi, Ajit, et al.
Publicado: (2023)

FRI021 Adipocyte Subpopulations Regulate The Lipolytic Response And Inflammatory Cytokine Action In Obesity
por: Huang, Jun, et al.
Publicado: (2023)

White Tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes
por: Söhle, Jörn, et al.
Publicado: (2009)

Comparison of Weight Reduction, Change in Parameters and Safety of a Very Low Carbohydrate Diet in Comparison to a Low Carbohydrate Diet in Obese Japanese Subjects with Metabolic Disorders
por: Kikuchi, Takako, et al.
Publicado: (2023)

Adipogenic and Lipolytic Effects of Ascorbic Acid in Ovariectomized Rats
por: Kim, Byoungjae, et al.
Publicado: (2018)

Comparisons between dipeptidyl peptidase-4 inhibitors and other classes of hypoglycemic drugs using two distinct biomarkers of pancreatic beta-cell function: A meta-analysis
por: Takahashi, Masahiro, et al.
Publicado: (2020)

Par14 interacts with the androgen receptor, augmenting both its transcriptional activity and prostate cancer proliferation
por: Naito, Miki, et al.
Publicado: (2022)

Lipolytic effect of novel extracts from mulberry (Morus alba) leaves fermented with Cordyceps militaris in the primary adipocytes derived from SD rats
por: Lee, Mi Rim, et al.
Publicado: (2017)

Effects of Phaseolus vulgaris Extract on Lipolytic Activity and Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes: A Strategy to Prevent Obesity
por: Castillo, Felipe, et al.
Publicado: (2019)

A mix of ginger phenols exhibits anti‑adipogenic and lipolytic effects in mature adipocytes derived from 3T3‑L1 cells
por: Gembe-Olivarez, Gildardo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sj2p7kbcbjevssh7bbhaons23a