Inhibition of HDAC6 Activity Alleviates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation

Patients with diabetes are more vulnerable to myocardial ischemia/reperfusion (MI/R) injury, which is associated with excessive reactive oxygen species (ROS) generation and decreased antioxidant defense. Histone deacetylase 6 (HDAC6), a regulator of the antioxidant protein peroxiredoxin 1 (Prdx1), i...

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Detalles Bibliográficos
Autores principales: Leng, Yan, Wu, Yang, Lei, Shaoqing, Zhou, Bin, Qiu, Zhen, Wang, Kai, Xia, Zhongyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036837/
https://www.ncbi.nlm.nih.gov/pubmed/30046381
http://dx.doi.org/10.1155/2018/9494052

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