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The emergence of long non-coding RNAs in hepatocellular carcinoma: an update
Hepatocellular carcinoma (HCC) accounting for roughly 90% of all primary liver neoplasms is the sixth most frequent neoplasm and the second prominent reason of tumor fatality worldwide. As regulators of diverse biological processes, long non-coding RNAs (lncRNAs) are involved in onset and developmen...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036883/ https://www.ncbi.nlm.nih.gov/pubmed/30026854 http://dx.doi.org/10.7150/jca.24560 |
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author | Peng, Li Yuan, Xiao-Qing Zhang, Chao-Yang Peng, Jiang-Yun Zhang, Ya-Qin Pan, Xi Li, Guan-Cheng |
author_facet | Peng, Li Yuan, Xiao-Qing Zhang, Chao-Yang Peng, Jiang-Yun Zhang, Ya-Qin Pan, Xi Li, Guan-Cheng |
author_sort | Peng, Li |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) accounting for roughly 90% of all primary liver neoplasms is the sixth most frequent neoplasm and the second prominent reason of tumor fatality worldwide. As regulators of diverse biological processes, long non-coding RNAs (lncRNAs) are involved in onset and development of neoplasms. With the continuous booming of well-featured lncRNAs in HCC from 2016 to now, we reviewed the newly-presented comprehension about the relationship between lncRNAs and HCC in this study. To be specific, we summarized the overview function and study tools of lncRNAs, elaborated the roles of lncRNAs in HCC, and sketched the molecule mechanisms of lncRNAs in HCC. In addition, the application of lncRNAs serving as biomarkers in early diagnosis and outcome prediction of HCC patients was highlighted. |
format | Online Article Text |
id | pubmed-6036883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-60368832018-07-19 The emergence of long non-coding RNAs in hepatocellular carcinoma: an update Peng, Li Yuan, Xiao-Qing Zhang, Chao-Yang Peng, Jiang-Yun Zhang, Ya-Qin Pan, Xi Li, Guan-Cheng J Cancer Review Hepatocellular carcinoma (HCC) accounting for roughly 90% of all primary liver neoplasms is the sixth most frequent neoplasm and the second prominent reason of tumor fatality worldwide. As regulators of diverse biological processes, long non-coding RNAs (lncRNAs) are involved in onset and development of neoplasms. With the continuous booming of well-featured lncRNAs in HCC from 2016 to now, we reviewed the newly-presented comprehension about the relationship between lncRNAs and HCC in this study. To be specific, we summarized the overview function and study tools of lncRNAs, elaborated the roles of lncRNAs in HCC, and sketched the molecule mechanisms of lncRNAs in HCC. In addition, the application of lncRNAs serving as biomarkers in early diagnosis and outcome prediction of HCC patients was highlighted. Ivyspring International Publisher 2018-06-22 /pmc/articles/PMC6036883/ /pubmed/30026854 http://dx.doi.org/10.7150/jca.24560 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Peng, Li Yuan, Xiao-Qing Zhang, Chao-Yang Peng, Jiang-Yun Zhang, Ya-Qin Pan, Xi Li, Guan-Cheng The emergence of long non-coding RNAs in hepatocellular carcinoma: an update |
title | The emergence of long non-coding RNAs in hepatocellular carcinoma: an update |
title_full | The emergence of long non-coding RNAs in hepatocellular carcinoma: an update |
title_fullStr | The emergence of long non-coding RNAs in hepatocellular carcinoma: an update |
title_full_unstemmed | The emergence of long non-coding RNAs in hepatocellular carcinoma: an update |
title_short | The emergence of long non-coding RNAs in hepatocellular carcinoma: an update |
title_sort | emergence of long non-coding rnas in hepatocellular carcinoma: an update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036883/ https://www.ncbi.nlm.nih.gov/pubmed/30026854 http://dx.doi.org/10.7150/jca.24560 |
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