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Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer

Colorectal cancer (CRC) is one of the major health threats in developed countries. Changes in dietary components, such as more protein and lipid intake, can increase the risk of CRC. Diet affects CRC in many ways. They regulate the composition and function of gut microbiota, which have an amazing me...

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Autores principales: Wu, Xinqiang, Wu, Yuanbing, He, Liangmei, Wu, Longhuo, Wang, Xiangcai, Liu, Zhiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036887/
https://www.ncbi.nlm.nih.gov/pubmed/30026849
http://dx.doi.org/10.7150/jca.25324
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author Wu, Xinqiang
Wu, Yuanbing
He, Liangmei
Wu, Longhuo
Wang, Xiangcai
Liu, Zhiping
author_facet Wu, Xinqiang
Wu, Yuanbing
He, Liangmei
Wu, Longhuo
Wang, Xiangcai
Liu, Zhiping
author_sort Wu, Xinqiang
collection PubMed
description Colorectal cancer (CRC) is one of the major health threats in developed countries. Changes in dietary components, such as more protein and lipid intake, can increase the risk of CRC. Diet affects CRC in many ways. They regulate the composition and function of gut microbiota, which have an amazing metabolic capacity and can produce short chain fatty acids (SCFAs), such as propionate, acetate, and butyrate. Butyrate is a principal energy source for colonic epithelial cells and plays an important role in maintaining the stability of gut microbiota and the integrity of intestinal epithelium. However, there are few studies reviewing the anti-CRC potentials of butyrate. This review summarizes the recent research progresses in the effect of gut microbiota imbalance and the decrease in intestinal microbial metabolite butyrate caused by unbalanced diet on CRC development, and discusses the mechanisms of butyrate-induced anti-CRC activities, which may guide people to prevent CRC by improving diet structures.
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spelling pubmed-60368872018-07-19 Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer Wu, Xinqiang Wu, Yuanbing He, Liangmei Wu, Longhuo Wang, Xiangcai Liu, Zhiping J Cancer Review Colorectal cancer (CRC) is one of the major health threats in developed countries. Changes in dietary components, such as more protein and lipid intake, can increase the risk of CRC. Diet affects CRC in many ways. They regulate the composition and function of gut microbiota, which have an amazing metabolic capacity and can produce short chain fatty acids (SCFAs), such as propionate, acetate, and butyrate. Butyrate is a principal energy source for colonic epithelial cells and plays an important role in maintaining the stability of gut microbiota and the integrity of intestinal epithelium. However, there are few studies reviewing the anti-CRC potentials of butyrate. This review summarizes the recent research progresses in the effect of gut microbiota imbalance and the decrease in intestinal microbial metabolite butyrate caused by unbalanced diet on CRC development, and discusses the mechanisms of butyrate-induced anti-CRC activities, which may guide people to prevent CRC by improving diet structures. Ivyspring International Publisher 2018-06-15 /pmc/articles/PMC6036887/ /pubmed/30026849 http://dx.doi.org/10.7150/jca.25324 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Wu, Xinqiang
Wu, Yuanbing
He, Liangmei
Wu, Longhuo
Wang, Xiangcai
Liu, Zhiping
Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer
title Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer
title_full Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer
title_fullStr Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer
title_full_unstemmed Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer
title_short Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer
title_sort effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036887/
https://www.ncbi.nlm.nih.gov/pubmed/30026849
http://dx.doi.org/10.7150/jca.25324
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