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miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk
Wilms tumor (WT) is the most prevalent urologic malignancy in childhood. Nonetheless, the genetic factors underlying WT remain largely unknown. The miR-423 rs6505162 C>A polymorphism is associated with the susceptibility to numerous cancers; however, no investigations have been conducted on its a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036889/ https://www.ncbi.nlm.nih.gov/pubmed/30026843 http://dx.doi.org/10.7150/jca.24916 |
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author | Fu, Wen Li, Li Xiong, Si-Wei Zhang, Tiesong Jia, Wei Zhu, Jinhong Zhao, Zhang Xia, Huimin He, Jing Liu, Guo-Chang |
author_facet | Fu, Wen Li, Li Xiong, Si-Wei Zhang, Tiesong Jia, Wei Zhu, Jinhong Zhao, Zhang Xia, Huimin He, Jing Liu, Guo-Chang |
author_sort | Fu, Wen |
collection | PubMed |
description | Wilms tumor (WT) is the most prevalent urologic malignancy in childhood. Nonetheless, the genetic factors underlying WT remain largely unknown. The miR-423 rs6505162 C>A polymorphism is associated with the susceptibility to numerous cancers; however, no investigations have been conducted on its association with WT. To evaluate the correlation between the miR-423 rs6505162 C>A polymorphism and WT risk in Chinese children, we genotyped this polymorphism using the Taqman method in 145 cases and 531 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the association. The results showed that the rs6505162 CA genotype was associated with decreased susceptibility to WT (CA versus CC: adjusted OR=0.65, 95% CI=0.42-0.99, P=0.047). In the stratified analysis, we found that CA/AA genotypes conferred a significantly decreased overall risk of WT in children younger than 18 months (adjusted OR=0.30, 95% CI=0.14-0.63, P=0.002) and those with clinical stage I+II WT (adjusted OR=0.42, 95% CI=0.20-0.85, P=0.017) when compared with CC genotype. In summary, the miR-423 rs6505162 C>A polymorphism may negatively modify WT susceptibility in Chinese children. Our findings should be validated in larger studies involving other ethnicities. |
format | Online Article Text |
id | pubmed-6036889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-60368892018-07-19 miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk Fu, Wen Li, Li Xiong, Si-Wei Zhang, Tiesong Jia, Wei Zhu, Jinhong Zhao, Zhang Xia, Huimin He, Jing Liu, Guo-Chang J Cancer Research Paper Wilms tumor (WT) is the most prevalent urologic malignancy in childhood. Nonetheless, the genetic factors underlying WT remain largely unknown. The miR-423 rs6505162 C>A polymorphism is associated with the susceptibility to numerous cancers; however, no investigations have been conducted on its association with WT. To evaluate the correlation between the miR-423 rs6505162 C>A polymorphism and WT risk in Chinese children, we genotyped this polymorphism using the Taqman method in 145 cases and 531 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the strength of the association. The results showed that the rs6505162 CA genotype was associated with decreased susceptibility to WT (CA versus CC: adjusted OR=0.65, 95% CI=0.42-0.99, P=0.047). In the stratified analysis, we found that CA/AA genotypes conferred a significantly decreased overall risk of WT in children younger than 18 months (adjusted OR=0.30, 95% CI=0.14-0.63, P=0.002) and those with clinical stage I+II WT (adjusted OR=0.42, 95% CI=0.20-0.85, P=0.017) when compared with CC genotype. In summary, the miR-423 rs6505162 C>A polymorphism may negatively modify WT susceptibility in Chinese children. Our findings should be validated in larger studies involving other ethnicities. Ivyspring International Publisher 2018-06-14 /pmc/articles/PMC6036889/ /pubmed/30026843 http://dx.doi.org/10.7150/jca.24916 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Fu, Wen Li, Li Xiong, Si-Wei Zhang, Tiesong Jia, Wei Zhu, Jinhong Zhao, Zhang Xia, Huimin He, Jing Liu, Guo-Chang miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk |
title | miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk |
title_full | miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk |
title_fullStr | miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk |
title_full_unstemmed | miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk |
title_short | miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk |
title_sort | mir-423 rs6505162 c>a polymorphism contributes to decreased wilms tumor risk |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036889/ https://www.ncbi.nlm.nih.gov/pubmed/30026843 http://dx.doi.org/10.7150/jca.24916 |
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