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Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study

Background: Although previous studies have explored the associations of modifiable lifestyle factors with oral cancer risk, few studies integrated these factors and established predictive tools for oral cancer risk in different sexes. Methods: Using a case-control study design, a total of 978 oral c...

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Autores principales: Chen, Fa, Lin, Lisong, Yan, Lingjun, Liu, Fengqiong, Qiu, Yu, Wang, Jing, Hu, Zhijian, Wu, Junfeng, Bao, Xiaodan, Lin, Liangkun, Wang, Rui, Cai, Guoxi, Aoyagi, Kiyoshi, Cai, Lin, He, Baochang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036893/
https://www.ncbi.nlm.nih.gov/pubmed/30026853
http://dx.doi.org/10.7150/jca.24431
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author Chen, Fa
Lin, Lisong
Yan, Lingjun
Liu, Fengqiong
Qiu, Yu
Wang, Jing
Hu, Zhijian
Wu, Junfeng
Bao, Xiaodan
Lin, Liangkun
Wang, Rui
Cai, Guoxi
Aoyagi, Kiyoshi
Cai, Lin
He, Baochang
author_facet Chen, Fa
Lin, Lisong
Yan, Lingjun
Liu, Fengqiong
Qiu, Yu
Wang, Jing
Hu, Zhijian
Wu, Junfeng
Bao, Xiaodan
Lin, Liangkun
Wang, Rui
Cai, Guoxi
Aoyagi, Kiyoshi
Cai, Lin
He, Baochang
author_sort Chen, Fa
collection PubMed
description Background: Although previous studies have explored the associations of modifiable lifestyle factors with oral cancer risk, few studies integrated these factors and established predictive tools for oral cancer risk in different sexes. Methods: Using a case-control study design, a total of 978 oral cancer cases and 2646 healthy controls were recruited in this study. Nomograms were constructed according to significant factors in multivariable logistic regression. Risk scores were calculated based on the nomograms and quantified the risk of oral cancer using restricted cubic spline. Results: Multivariate analyses demonstrated that smoking, alcohol drinking, tea, intake of fish, seafood, vegetables, fruits, teeth loss, regular dental visits and repetitive dental ulcer were independent factors for male oral cancer. Passive smoking, age at first intercourse, cooking oil fumes exposure, tea, intake of beans, vegetables, fruits, teeth loss, regular dental visits and repetitive dental ulcer were associated with female oral cancer. Then, two nomograms were developed for predicting the probability of oral cancer in men and women with the C-index of 0.768 (95% CI: 0.723-0.813) and 0.700 (95% CI: 0.635-0.765), respectively. Restricted cubic splines graphically revealed the risk of oral cancer in individuals with different risk scores. Moreover, the risk escalated continuously with the increasing number of the risk scores among both sexes. Conclusions: Combining nomograms with risk scores developed in this study could precisely predict oral cancer occurrence and provide an accurate risk assessment.
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spelling pubmed-60368932018-07-19 Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study Chen, Fa Lin, Lisong Yan, Lingjun Liu, Fengqiong Qiu, Yu Wang, Jing Hu, Zhijian Wu, Junfeng Bao, Xiaodan Lin, Liangkun Wang, Rui Cai, Guoxi Aoyagi, Kiyoshi Cai, Lin He, Baochang J Cancer Research Paper Background: Although previous studies have explored the associations of modifiable lifestyle factors with oral cancer risk, few studies integrated these factors and established predictive tools for oral cancer risk in different sexes. Methods: Using a case-control study design, a total of 978 oral cancer cases and 2646 healthy controls were recruited in this study. Nomograms were constructed according to significant factors in multivariable logistic regression. Risk scores were calculated based on the nomograms and quantified the risk of oral cancer using restricted cubic spline. Results: Multivariate analyses demonstrated that smoking, alcohol drinking, tea, intake of fish, seafood, vegetables, fruits, teeth loss, regular dental visits and repetitive dental ulcer were independent factors for male oral cancer. Passive smoking, age at first intercourse, cooking oil fumes exposure, tea, intake of beans, vegetables, fruits, teeth loss, regular dental visits and repetitive dental ulcer were associated with female oral cancer. Then, two nomograms were developed for predicting the probability of oral cancer in men and women with the C-index of 0.768 (95% CI: 0.723-0.813) and 0.700 (95% CI: 0.635-0.765), respectively. Restricted cubic splines graphically revealed the risk of oral cancer in individuals with different risk scores. Moreover, the risk escalated continuously with the increasing number of the risk scores among both sexes. Conclusions: Combining nomograms with risk scores developed in this study could precisely predict oral cancer occurrence and provide an accurate risk assessment. Ivyspring International Publisher 2018-06-22 /pmc/articles/PMC6036893/ /pubmed/30026853 http://dx.doi.org/10.7150/jca.24431 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Chen, Fa
Lin, Lisong
Yan, Lingjun
Liu, Fengqiong
Qiu, Yu
Wang, Jing
Hu, Zhijian
Wu, Junfeng
Bao, Xiaodan
Lin, Liangkun
Wang, Rui
Cai, Guoxi
Aoyagi, Kiyoshi
Cai, Lin
He, Baochang
Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study
title Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study
title_full Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study
title_fullStr Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study
title_full_unstemmed Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study
title_short Nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study
title_sort nomograms and risk scores for predicting the risk of oral cancer in different sexes: a large-scale case-control study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036893/
https://www.ncbi.nlm.nih.gov/pubmed/30026853
http://dx.doi.org/10.7150/jca.24431
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