Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy

Molecular imaging of the immune checkpoint receptor PD-1 and its ligand PD-L1 is increasingly investigated as a strategy to guide and monitor PD-1:PD-L1-targeted immune checkpoint therapy. We provide an overview of the current state-of-the-art on PD-1- and PD-L1-specific imaging agents for quantitat...

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Detalles Bibliográficos
Autores principales: Broos, Katrijn, Lecocq, Quentin, Raes, Geert, Devoogdt, Nick, Keyaerts, Marleen, Breckpot, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037030/
https://www.ncbi.nlm.nih.gov/pubmed/30026866
http://dx.doi.org/10.7150/thno.24762
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author Broos, Katrijn
Lecocq, Quentin
Raes, Geert
Devoogdt, Nick
Keyaerts, Marleen
Breckpot, Karine
author_facet Broos, Katrijn
Lecocq, Quentin
Raes, Geert
Devoogdt, Nick
Keyaerts, Marleen
Breckpot, Karine
author_sort Broos, Katrijn
collection PubMed
description Molecular imaging of the immune checkpoint receptor PD-1 and its ligand PD-L1 is increasingly investigated as a strategy to guide and monitor PD-1:PD-L1-targeted immune checkpoint therapy. We provide an overview of the current state-of-the-art on PD-1- and PD-L1-specific imaging agents for quantitative, real-time assessment of PD-1:PD-L1 expression in the tumor environment and discuss their potential for clinical translation.
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spelling pubmed-60370302018-07-19 Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy Broos, Katrijn Lecocq, Quentin Raes, Geert Devoogdt, Nick Keyaerts, Marleen Breckpot, Karine Theranostics Review Molecular imaging of the immune checkpoint receptor PD-1 and its ligand PD-L1 is increasingly investigated as a strategy to guide and monitor PD-1:PD-L1-targeted immune checkpoint therapy. We provide an overview of the current state-of-the-art on PD-1- and PD-L1-specific imaging agents for quantitative, real-time assessment of PD-1:PD-L1 expression in the tumor environment and discuss their potential for clinical translation. Ivyspring International Publisher 2018-06-07 /pmc/articles/PMC6037030/ /pubmed/30026866 http://dx.doi.org/10.7150/thno.24762 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Broos, Katrijn
Lecocq, Quentin
Raes, Geert
Devoogdt, Nick
Keyaerts, Marleen
Breckpot, Karine
Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy
title Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy
title_full Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy
title_fullStr Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy
title_full_unstemmed Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy
title_short Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy
title_sort noninvasive imaging of the pd-1:pd-l1 immune checkpoint: embracing nuclear medicine for the benefit of personalized immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037030/
https://www.ncbi.nlm.nih.gov/pubmed/30026866
http://dx.doi.org/10.7150/thno.24762
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