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A Population-Based Surveillance Study on the Epidemiology of Hepatitis C in Estonia

Background and objective: The hepatitis C virus (HCV)-infected patients serve as a reservoir for transmission of the disease to others and are at risk of developing chronic hepatitis C, cirrhosis, and hepatocellular carcinoma. Although the epidemiological data of high rate HCV infection have been ob...

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Autores principales: Mansberg, Kairi, Kull, Karin, Salupere, Riina, Prükk, Tiina, Margus, Benno, Kariis, Toomas, Remmel, Triin, Suurmaa, Külliki, Ott, Kristi, Jaago, Krista, Šmidt, Jelena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037246/
https://www.ncbi.nlm.nih.gov/pubmed/30344240
http://dx.doi.org/10.3390/medicina54010009
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author Mansberg, Kairi
Kull, Karin
Salupere, Riina
Prükk, Tiina
Margus, Benno
Kariis, Toomas
Remmel, Triin
Suurmaa, Külliki
Ott, Kristi
Jaago, Krista
Šmidt, Jelena
author_facet Mansberg, Kairi
Kull, Karin
Salupere, Riina
Prükk, Tiina
Margus, Benno
Kariis, Toomas
Remmel, Triin
Suurmaa, Külliki
Ott, Kristi
Jaago, Krista
Šmidt, Jelena
author_sort Mansberg, Kairi
collection PubMed
description Background and objective: The hepatitis C virus (HCV)-infected patients serve as a reservoir for transmission of the disease to others and are at risk of developing chronic hepatitis C, cirrhosis, and hepatocellular carcinoma. Although the epidemiological data of high rate HCV infection have been obtained in many countries, such data are insufficient in Estonia. Therefore, the aim of the study was to analyze country-specific data on HCV patients. Materials and methods: Data about age, gender, diagnosis, possible risk factors, coinfections, HCV genotypes, liver fibrosis stages and extrahepatic manifestations were collected from 518 patients. Results: The most common risk factors for hepatitis C were injection drug use and tattooing in the 30–39 and 40–49 year age groups, and blood transfusion in the 50–59 and 60–69 year age groups. The other risk factors established were profession-related factors and sexual contact. The prevailing viral genotype among the HCV infected patients was genotype 1 (69% of the patients) followed by genotype 3 (25%). Genotypes 1 and 3 correlated with blood transfusions before 1994, drug injections and tattooing. Conclusions: Our study provides the best representation of genotype distribution across Estonia. As a result of the study, valuable data has been collected on hepatitis C patients in Estonia.
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spelling pubmed-60372462018-10-18 A Population-Based Surveillance Study on the Epidemiology of Hepatitis C in Estonia Mansberg, Kairi Kull, Karin Salupere, Riina Prükk, Tiina Margus, Benno Kariis, Toomas Remmel, Triin Suurmaa, Külliki Ott, Kristi Jaago, Krista Šmidt, Jelena Medicina (Kaunas) Article Background and objective: The hepatitis C virus (HCV)-infected patients serve as a reservoir for transmission of the disease to others and are at risk of developing chronic hepatitis C, cirrhosis, and hepatocellular carcinoma. Although the epidemiological data of high rate HCV infection have been obtained in many countries, such data are insufficient in Estonia. Therefore, the aim of the study was to analyze country-specific data on HCV patients. Materials and methods: Data about age, gender, diagnosis, possible risk factors, coinfections, HCV genotypes, liver fibrosis stages and extrahepatic manifestations were collected from 518 patients. Results: The most common risk factors for hepatitis C were injection drug use and tattooing in the 30–39 and 40–49 year age groups, and blood transfusion in the 50–59 and 60–69 year age groups. The other risk factors established were profession-related factors and sexual contact. The prevailing viral genotype among the HCV infected patients was genotype 1 (69% of the patients) followed by genotype 3 (25%). Genotypes 1 and 3 correlated with blood transfusions before 1994, drug injections and tattooing. Conclusions: Our study provides the best representation of genotype distribution across Estonia. As a result of the study, valuable data has been collected on hepatitis C patients in Estonia. MDPI 2018-03-25 /pmc/articles/PMC6037246/ /pubmed/30344240 http://dx.doi.org/10.3390/medicina54010009 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mansberg, Kairi
Kull, Karin
Salupere, Riina
Prükk, Tiina
Margus, Benno
Kariis, Toomas
Remmel, Triin
Suurmaa, Külliki
Ott, Kristi
Jaago, Krista
Šmidt, Jelena
A Population-Based Surveillance Study on the Epidemiology of Hepatitis C in Estonia
title A Population-Based Surveillance Study on the Epidemiology of Hepatitis C in Estonia
title_full A Population-Based Surveillance Study on the Epidemiology of Hepatitis C in Estonia
title_fullStr A Population-Based Surveillance Study on the Epidemiology of Hepatitis C in Estonia
title_full_unstemmed A Population-Based Surveillance Study on the Epidemiology of Hepatitis C in Estonia
title_short A Population-Based Surveillance Study on the Epidemiology of Hepatitis C in Estonia
title_sort population-based surveillance study on the epidemiology of hepatitis c in estonia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037246/
https://www.ncbi.nlm.nih.gov/pubmed/30344240
http://dx.doi.org/10.3390/medicina54010009
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