Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling

Ferrochelatase (FECH) is an enzyme necessary for heme synthesis, which is essential for maintaining normal functions of endothelial nitric oxide synthase (eNOS) and soluble guanylyl cyclase (sGC). We tested the hypothesis that inhibition of vascular FECH to attenuate heme synthesis downregulates eNO...

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Detalles Bibliográficos
Autores principales: Zhang, Bin, Alruwaili, Norah, Kandhi, Sharath, Deng, Wensheng, Huang, An, Wolin, Michael S., Sun, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037352/
https://www.ncbi.nlm.nih.gov/pubmed/29985945
http://dx.doi.org/10.1371/journal.pone.0200307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037352/
https://www.ncbi.nlm.nih.gov/pubmed/29985945
http://dx.doi.org/10.1371/journal.pone.0200307

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