Cargando…

Inhibition of ferrochelatase impairs vascular eNOS/NO and sGC/cGMP signaling

Ferrochelatase (FECH) is an enzyme necessary for heme synthesis, which is essential for maintaining normal functions of endothelial nitric oxide synthase (eNOS) and soluble guanylyl cyclase (sGC). We tested the hypothesis that inhibition of vascular FECH to attenuate heme synthesis downregulates eNO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Bin, Alruwaili, Norah, Kandhi, Sharath, Deng, Wensheng, Huang, An, Wolin, Michael S., Sun, Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037352/ https://www.ncbi.nlm.nih.gov/pubmed/29985945 http://dx.doi.org/10.1371/journal.pone.0200307

Ejemplares similares

Redox regulation of responses to hypoxia and NO-cGMP signaling in pulmonary vascular pathophysiology
por: Wolin, Michael S, et al.
Publicado: (2011)

Is Innervation of the Neuromuscular Junction at the Diaphragm Modulated by sGC/cGMP Signaling?
por: Lukáčová, Nadežda, et al.
Publicado: (2020)

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function
por: Gambaryan, Stepan
Publicado: (2022)

Vasorelaxation Induced by a New Naphthoquinone-Oxime is Mediated by NO-sGC-cGMP Pathway
por: Dantas, Bruna P. V., et al.
Publicado: (2014)

Treatment of pediatric pulmonary arterial hypertension: A focus on the NO‐sGC‐cGMP pathway
por: Beghetti, Maurice, et al.
Publicado: (2019)

Effect of L-carnitine supplementation on the sGC/cGMP pathway in vascular relaxing responses from exercised rats
por: Priviero, Fernanda BM, et al.
Publicado: (2009)

L-arginine supplementation improves aortic vascular relaxation via NO-independent sGC/cGMP signaling in exercised rats
por: Zanesco, Angelina, et al.
Publicado: (2009)

Hypoxia/Reoxygenation of Rat Renal Arteries Impairs Vasorelaxation via Modulation of Endothelium-Independent sGC/cGMP/PKG Signaling
por: Braun, Diana, et al.
Publicado: (2018)

Bee Bread Ameliorates Vascular Inflammation and Impaired Vasorelaxation in Obesity-Induced Vascular Damage Rat Model: The Role of eNOS/NO/cGMP-Signaling Pathway
por: Othman, Zaidatul Akmal, et al.
Publicado: (2021)

Nitrite mediated vasorelaxation in human chorionic plate vessels is enhanced by hypoxia and dependent on the NO-sGC-cGMP pathway
por: Tropea, Teresa, et al.
Publicado: (2018)

Magnesium Lithospermate B, an Active Extract of Salvia miltiorrhiza, Mediates sGC/cGMP/PKG Translocation in Experimental Vasospasm
por: Chang, Chih-Zen, et al.
Publicado: (2014)

Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway
por: Badran, Adnan, et al.
Publicado: (2019)

Corrigendum to “Magnesium Lithospermate B, an Active Extract of Salvia miltiorrhiza, Mediates sGC/cGMP/PKG Translocation in Experimental Vasospasm”
por: Chang, Chih-Zen, et al.
Publicado: (2016)

A systems biology approach to cGMP suggests a prominent role for sGC in stroke: Validation by mechanism-based activation of apo-sGC in non-steal dosing coveys neuroprotection and increased survival
por: Casas, Ana I, et al.
Publicado: (2015)

Astragaloside IV promotes the eNOS/NO/cGMP pathway and improves left ventricular diastolic function in rats with metabolic syndrome
por: Lin, Xin, et al.
Publicado: (2019)

Helicid Reverses the Effect of Overexpressing NCALD, Which Blocks the sGC/cGMP/PKG Signaling Pathway in the CUMS-Induced Rat Model
por: Zhang, Xiao-Tong, et al.
Publicado: (2021)

LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway
por: Chen, Ting, et al.
Publicado: (2022)

CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway
por: Katsouda, Antonia, et al.
Publicado: (2023)

Age, noise and cGMP: Pharmacological activation of soluble guanylyl cyclase (sGC) interacts with the progression of age related and noise induced hearing loss
por: Rüttiger, Lukas, et al.
Publicado: (2015)

Retracted: Helicid Reverses the Effect of Overexpressing NCALD, Which Blocks the sGC/cGMP/PKG Signaling Pathway in the CUMS-Induced Rat Model
por: Healthcare Engineering, Journal of
Publicado: (2023)

Superoxide-Mediated Upregulation of MMP9 Participates in BMPR2 Destabilization and Pulmonary Hypertension Development
por: Alruwaili, Norah, et al.
Publicado: (2023)

Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways
por: Lee, Mei-Yueh, et al.
Publicado: (2016)

The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate
por: Wang, Chao, et al.
Publicado: (2016)

BAY 41-2272 Attenuates CTGF Expression via sGC/cGMP-Independent Pathway in TGFβ1-Activated Hepatic Stellate Cells
por: Chen, Po-Jen, et al.
Publicado: (2020)

Ulinastatin Inhibits the Proliferation, Invasion and Phenotypic Switching of PDGF-BB-Induced VSMCs via Akt/eNOS/NO/cGMP Signaling Pathway
por: Huang, Cheng, et al.
Publicado: (2020)

Salvia fruticosa Induces Vasorelaxation In Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway
por: Anwar, M. Akhtar, et al.
Publicado: (2017)

REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS/NO/cGMP pathway and supplementation with L-arginine
por: Jiang, Jiaye, et al.
Publicado: (2017)

Vascular and renal function of cGMP signalling
por: Schlossmann, Jens, et al.
Publicado: (2011)

cGMP and PKGI are required for vascular BMP signaling
por: Schwappacher, Raphaela, et al.
Publicado: (2011)

Structural insights into sGC
por: Akker, Focco van den, et al.
Publicado: (2009)

Age- and Hypertension-Related Changes in NOS/NO/sGC-Derived Vasoactive Control of Rat Thoracic Aortae
por: Berenyiova, Andrea, et al.
Publicado: (2022)

Activation of the iNOS/NO/cGMP pathway by Revactin® in human corporal smooth muscle cells
por: Ferrini, Monica G., et al.
Publicado: (2021)

cGMP Signaling and Vascular Smooth Muscle Cell Plasticity
por: Lehners, Moritz, et al.
Publicado: (2018)

Molecular aspects of sGC regulation
por: Marletta, Michael A, et al.
Publicado: (2011)

Targeting native and apo-sGC
por: Struthers, Mary, et al.
Publicado: (2013)

sGC redox regulation and asthma
por: Stuehr, Dennis J, et al.
Publicado: (2015)

NO/cGMP signalling in platelets
por: Schinner, Elisabeth, et al.
Publicado: (2009)

cGMP and cardiac hypertrophy
por: Perera, Ruwan K, et al.
Publicado: (2015)

Analysis of cGMP signalling with transgenic mice expressing FRET-based cGMP sensors
por: Wen, Lai, et al.
Publicado: (2013)

SUN-551 Impaired Vascular Relaxation and Altered eNOS Regulation in Boys with Hypospadias
por: Lucas-Herald, Angela K, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qgjn91du0fjsnjqnmac9inkk23