Cargando…

The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation

In yeast, the glucose-induced degradation-deficient (GID) E3 ligase selectively degrades superfluous gluconeogenic enzymes. Here, we identified all subunits of the mammalian GID/CTLH complex and provide a comprehensive map of its hierarchical organization and step-wise assembly. Biochemical reconsti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lampert, Fabienne, Stafa, Diana, Goga, Algera, Soste, Martin Varis, Gilberto, Samuel, Olieric, Natacha, Picotti, Paola, Stoffel, Markus, Peter, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037477/ https://www.ncbi.nlm.nih.gov/pubmed/29911972 http://dx.doi.org/10.7554/eLife.35528

Ejemplares similares

Structural and Functional Insights into GID/CTLH E3 Ligase Complexes
por: Maitland, Matthew E. R., et al.
Publicado: (2022)

Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components
por: Hantel, Friederike, et al.
Publicado: (2022)

Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4
por: Chana, Chetan K., et al.
Publicado: (2022)

Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system
por: Yang, Xi, et al.
Publicado: (2018)

The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation
por: Maitland, Matthew E. R., et al.
Publicado: (2019)

Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1
por: Peterson, Brian G, et al.
Publicado: (2019)

The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan
por: Liu, Huaize, et al.
Publicado: (2019)

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation
por: Faust, Tyler B, et al.
Publicado: (2018)

A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes
por: Gschweitl, Michaela, et al.
Publicado: (2016)

Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex‐dependent regulation of glycolysis
por: Maitland, Matthew E. R., et al.
Publicado: (2021)

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism
por: Ahel, Juraj, et al.
Publicado: (2020)

Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase
por: Kong, Ka-Yiu Edwin, et al.
Publicado: (2021)

Molecular architecture of the human tRNA ligase complex
por: Kroupova, Alena, et al.
Publicado: (2021)

The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains
por: Rodriguez Carvajal, Alan, et al.
Publicado: (2021)

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4
por: Foresti, Ombretta, et al.
Publicado: (2013)

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle
por: Mosadeghi, Ruzbeh, et al.
Publicado: (2016)

Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation
por: Nemoto, Keiichirou, et al.
Publicado: (2017)

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme
por: Sherpa, Dawafuti, et al.
Publicado: (2021)

Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase
por: Courtheoux, Thibault, et al.
Publicado: (2016)

Heterogeneity in conservation of multifunctional partner enzymes with meiotic importance, CDK2 kinase and BRCA1 ubiquitin ligase
por: Matveevsky, Sergey, et al.
Publicado: (2021)

Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions
por: Werner, Achim, et al.
Publicado: (2018)

Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways
por: Hill, Spencer, et al.
Publicado: (2019)

Corrigendum: Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase
por: Courtheoux, Thibault, et al.
Publicado: (2016)

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ
por: Watanabe, Masashi, et al.
Publicado: (2015)

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function
por: Coleman, Kate E, et al.
Publicado: (2017)

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids
por: Hoxhaj, Gerta, et al.
Publicado: (2016)

Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection
por: Shin, Donghyuk, et al.
Publicado: (2020)

Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atpyical role for an old cofactor
por: Cao, Xinyun, et al.
Publicado: (2018)

Deamidation disrupts native and transient contacts to weaken the interaction between UBC13 and RING-finger E3 ligases
por: Mohanty, Priyesh, et al.
Publicado: (2019)

Molecular Phylogeny of a RING E3 Ubiquitin Ligase, Conserved in Eukaryotic Cells and Dominated by Homologous Components, the Muskelin/RanBPM/CTLH Complex
por: Francis, Ore, et al.
Publicado: (2013)

tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay
por: Peschek, Jirka, et al.
Publicado: (2019)

A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters
por: Langlois, Christine R, et al.
Publicado: (2022)

Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway
por: Wang, Zheng, et al.
Publicado: (2018)

Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
por: Mehta, Ved, et al.
Publicado: (2022)

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation
por: Patil, Gajanan S, et al.
Publicado: (2021)

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
por: Eapen, Vinay V, et al.
Publicado: (2021)

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions
por: Song, Aixin, et al.
Publicado: (2021)

The CTLH Complex in Cancer Cell Plasticity
por: Huffman, Nickelas, et al.
Publicado: (2019)

Correction: Molecular Phylogeny of a RING E3 Ubiquitin Ligase, Conserved in Eukaryotic Cells and Dominated by Homologous Components, the Muskelin/RanBPM/CTLH Complex
por: Francis, Ore, et al.
Publicado: (2013)

Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase
por: Fujisawa, Ryo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q52sfe7pk0gvkpjid7d58us8da