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Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis
In this study, we demonstrate, for the first time, that Saccharomyces cerevisiae-based probiotic shows an inhibitory effect on Gardnerella vaginalis infection. This effect is likely due to several actions: direct interference with adherence to vaginal tissues, inhibition of sialidase activity, reduc...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037478/ https://www.ncbi.nlm.nih.gov/pubmed/29683763 http://dx.doi.org/10.1080/21505594.2018.1464362 |
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| author | Sabbatini, Samuele Monari, Claudia Ballet, Nathalie Mosci, Paolo Decherf, Amélie Cayzeele Pélerin, Fanny Perito, Stefano Scarpelli, Paolo Vecchiarelli, Anna |
| author_facet | Sabbatini, Samuele Monari, Claudia Ballet, Nathalie Mosci, Paolo Decherf, Amélie Cayzeele Pélerin, Fanny Perito, Stefano Scarpelli, Paolo Vecchiarelli, Anna |
| author_sort | Sabbatini, Samuele |
| collection | PubMed |
| description | In this study, we demonstrate, for the first time, that Saccharomyces cerevisiae-based probiotic shows an inhibitory effect on Gardnerella vaginalis infection. This effect is likely due to several actions: direct interference with adherence to vaginal tissues, inhibition of sialidase activity, reduction of vaginal epithelial exfoliation. Gardnerella vaginalis does not induce vaginal inflammation and no inflammatory cytokines were, indeed, produced, by the mouse vagina, neither by Gardnerella vaginalis and by the probiotic. Collectively, our data incite to further investigations on Saccharomyces cerevisiae probiotic as a potential prophylactic or therapeutic agent in the vaginosis caused by Gardnerella vaginalis. |
| format | Online Article Text |
| id | pubmed-6037478 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-60374782018-07-11 Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis Sabbatini, Samuele Monari, Claudia Ballet, Nathalie Mosci, Paolo Decherf, Amélie Cayzeele Pélerin, Fanny Perito, Stefano Scarpelli, Paolo Vecchiarelli, Anna Virulence Research Paper In this study, we demonstrate, for the first time, that Saccharomyces cerevisiae-based probiotic shows an inhibitory effect on Gardnerella vaginalis infection. This effect is likely due to several actions: direct interference with adherence to vaginal tissues, inhibition of sialidase activity, reduction of vaginal epithelial exfoliation. Gardnerella vaginalis does not induce vaginal inflammation and no inflammatory cytokines were, indeed, produced, by the mouse vagina, neither by Gardnerella vaginalis and by the probiotic. Collectively, our data incite to further investigations on Saccharomyces cerevisiae probiotic as a potential prophylactic or therapeutic agent in the vaginosis caused by Gardnerella vaginalis. Taylor & Francis 2018-05-29 /pmc/articles/PMC6037478/ /pubmed/29683763 http://dx.doi.org/10.1080/21505594.2018.1464362 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Paper Sabbatini, Samuele Monari, Claudia Ballet, Nathalie Mosci, Paolo Decherf, Amélie Cayzeele Pélerin, Fanny Perito, Stefano Scarpelli, Paolo Vecchiarelli, Anna Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis |
| title | Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis |
| title_full | Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis |
| title_fullStr | Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis |
| title_full_unstemmed | Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis |
| title_short | Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis |
| title_sort | saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis |
| topic | Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037478/ https://www.ncbi.nlm.nih.gov/pubmed/29683763 http://dx.doi.org/10.1080/21505594.2018.1464362 |
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