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Engineering ER-stress dependent non-conventional mRNA splicing

The endoplasmic reticulum (ER) protein folding capacity is balanced with the protein folding burden to prevent accumulation of un- or misfolded proteins. The ER membrane-resident kinase/RNase Ire1 maintains ER protein homeostasis through two fundamentally distinct processes. First, Ire1 can initiate...

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Detalles Bibliográficos
Autores principales:	Li, Weihan, Okreglak, Voytek, Peschek, Jirka, Kimmig, Philipp, Zubradt, Meghan, Weissman, Jonathan S, Walter, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037481/ https://www.ncbi.nlm.nih.gov/pubmed/29985129 http://dx.doi.org/10.7554/eLife.35388

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