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Helix α-3 inter-molecular salt bridges and conformational changes are essential for toxicity of Bacillus thuringiensis 3D-Cry toxin family

Bacillus thuringiensis insecticidal Cry toxins break down larval midgut-cells after forming pores. The 3D-structures of Cry4Ba and Cry5Ba revealed a trimeric-oligomer after cleavage of helices α-1 and α-2a, where helix α-3 is extended and made contacts with adjacent monomers. Molecular dynamic simul...

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Detalles Bibliográficos
Autores principales:	Pacheco, Sabino, Gómez, Isabel, Sánchez, Jorge, García-Gómez, Blanca-Ines, Czajkowsky, Daniel M., Zhang, Jie, Soberón, Mario, Bravo, Alejandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037675/ https://www.ncbi.nlm.nih.gov/pubmed/29985464 http://dx.doi.org/10.1038/s41598-018-28753-8

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