AAV vector-mediated in vivo reprogramming into pluripotency

In vivo reprogramming of somatic cells into induced pluripotent stem cells (iPSC) holds vast potential for basic research and regenerative medicine. However, it remains hampered by a need for vectors to express reprogramming factors (Oct-3/4, Klf4, Sox2, c-Myc; OKSM) in selected organs. Here, we rep...

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Detalles Bibliográficos
Autores principales: Senís, Elena, Mosteiro, Lluc, Wilkening, Stefan, Wiedtke, Ellen, Nowrouzi, Ali, Afzal, Saira, Fronza, Raffaele, Landerer, Henrik, Abad, Maria, Niopek, Dominik, Schmidt, Manfred, Serrano, Manuel, Grimm, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037684/
https://www.ncbi.nlm.nih.gov/pubmed/29985406
http://dx.doi.org/10.1038/s41467-018-05059-x

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