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Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam

Many GABAergic drugs are in clinical use as anesthetics, sedatives, or anxiolytics. We have investigated the actions of the combinations of the neuroactive steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with the intravenous anesthetic propofol or the benzodiazepine diazepam. The goal of the...

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Detalles Bibliográficos
Autores principales:	Cao, Lily Q., Montana, Michael C., Germann, Allison L., Shin, Daniel J., Chakrabarti, Sampurna, Mennerick, Steven, Yuede, Carla M., Wozniak, David F., Evers, Alex S., Akk, Gustav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037692/ https://www.ncbi.nlm.nih.gov/pubmed/29985445 http://dx.doi.org/10.1038/s41598-018-28754-7

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