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TCR signal strength controls thymic differentiation of iNKT cell subsets

During development in the thymus, invariant natural killer T (iNKT) cells commit to one of three major functionally different subsets, iNKT1, iNKT2, and iNKT17. Here, we show that T cell antigen receptor (TCR) signal strength governs the development of iNKT cell subsets, with strong signaling promot...

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Detalles Bibliográficos
Autores principales:	Tuttle, Kathryn D., Krovi, S. Harsha, Zhang, Jingjing, Bedel, Romain, Harmacek, Laura, Peterson, Lisa K., Dragone, Leonard L., Lefferts, Adam, Halluszczak, Catherine, Riemondy, Kent, Hesselberth, Jay R., Rao, Anjana, O’Connor, Brian P., Marrack, Philippa, Scott-Browne, James, Gapin, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037704/ https://www.ncbi.nlm.nih.gov/pubmed/29985393 http://dx.doi.org/10.1038/s41467-018-05026-6

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