Downregulation of miR-130a, antagonized doxorubicin-induced cardiotoxicity via increasing the PPARγ expression in mESCs-derived cardiac cells

Doxorubicin (Dox) is a widely used powerful chemotherapeutic component for cancer treatment. However, its clinical application has been hampered due to doxorubicin-induced cardiomyopathy upon the cessation of chemotherapy. Previous studies revealed that PPARγ plays a crucial protective role in cardi...

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Detalles Bibliográficos
Autores principales: Pakravan, Golnaz, Foroughmand, Ali Mohammad, Peymani, Maryam, Ghaedi, Kamran, Hashemi, Motahare-Sadat, Hajjari, Mohammadreza, Nasr-Esfahani, Mohammad Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037713/
https://www.ncbi.nlm.nih.gov/pubmed/29988029
http://dx.doi.org/10.1038/s41419-018-0797-1

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