Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

Glutathione (GSH) protects against oxidative damage in many tissues, including retinal pigment epithelium (RPE). Oxidative stress-mediated senescence and death of RPE and subsequent death of photoreceptors have been observed in age-related macular degeneration (AMD). Although the consequences of GSH...

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Detalles Bibliográficos
Autores principales: Sun, Yun, Zheng, Yingfeng, Wang, Chunxiao, Liu, Yizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037763/
https://www.ncbi.nlm.nih.gov/pubmed/29988039
http://dx.doi.org/10.1038/s41419-018-0794-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037763/
https://www.ncbi.nlm.nih.gov/pubmed/29988039
http://dx.doi.org/10.1038/s41419-018-0794-4

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