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The active site residues Gln55 and Arg73 play a key role in DNA damage bypass by S. cerevisiae Pol η
Eukaryotic DNA polymerase eta (Pol η) plays a key role in the efficient and accurate DNA translesion synthesis (TLS) opposite UV-induced thymine dimers. Pol η is also involved in bypass of many other DNA lesions but possesses low fidelity on undamaged DNA templates. To better understand the mechanis...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037775/ https://www.ncbi.nlm.nih.gov/pubmed/29985422 http://dx.doi.org/10.1038/s41598-018-28664-8 |