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Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics
Glioblastoma Multiforme (GBM) is known to be one of the most malignant and aggressive forms of brain cancer due to its resistance to chemotherapy. Recently, GBM was found to not only utilise both oxidative phosphorylation (OXPHOS) and aerobic glycolysis, but also depend on the bulk protein degradati...
Autores principales: | Kriel, Jurgen, Müller-Nedebock, Kristian, Maarman, Gerald, Mbizana, Siyasanga, Ojuka, Edward, Klumperman, Bert, Loos, Ben |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037778/ https://www.ncbi.nlm.nih.gov/pubmed/29985441 http://dx.doi.org/10.1038/s41598-018-28590-9 |
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