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Haplotypic and Genotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia
Treatment-resistant schizophrenia (TRS) continues to be a challenge. It was related to different factors, including alterations in the activity of brain dopaminergic system, which could be influenced by the dopamine-degrading enzyme, catechol-O-methyltransferase (COMT). Variants of the COMT gene hav...
Autores principales: | Sagud, Marina, Tudor, Lucija, Uzun, Suzana, Perkovic, Matea Nikolac, Zivkovic, Maja, Konjevod, Marcela, Kozumplik, Oliver, Vuksan Cusa, Bjanka, Svob Strac, Dubravka, Rados, Iva, Mimica, Ninoslav, Mihaljevic Peles, Alma, Nedic Erjavec, Gordana, Pivac, Nela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037851/ https://www.ncbi.nlm.nih.gov/pubmed/30018555 http://dx.doi.org/10.3389/fphar.2018.00705 |
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