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Design of Diarylheptanoid Derivatives as Dual Inhibitors Against Class IIa Histone Deacetylase and β-amyloid Aggregation

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with multiple etiologies. Beta-amyloid (Aβ) self-aggregation and overexpression of class IIa histone deacetylases (HDACs) are strongly implicated with AD pathogenesis. In this study, a series of novel diarylheptanoid derivatives we...

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Detalles Bibliográficos
Autores principales:	Chen, Liang-Chieh, Tseng, Hui-Ju, Liu, Chang-Yi, Huang, Yun-Yi, Yen, Cheng-Chung, Weng, Jing-Ru, Lu, Yeh-Lin, Hou, Wen-Chi, Lin, Tony E., Pan, I-Horng, Huang, Kuo-Kuei, Huang, Wei-Jan, Hsu, Kai-Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037852/ https://www.ncbi.nlm.nih.gov/pubmed/30018556 http://dx.doi.org/10.3389/fphar.2018.00708

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