Telomerase-Mediated Strategy for Overcoming Non–Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance

Standard and targeted cancer therapies for late-stage cancer patients almost universally fail due to tumor heterogeneity/plasticity and intrinsic or acquired drug resistance. We used the telomerase substrate nucleoside precursor, 6-thio-2′-deoxyguanosine (6-thio-dG), to target telomerase-expressing...

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Detalles Bibliográficos
Autores principales: Mender, Ilgen, LaRanger, Ryan, Luitel, Krishna, Peyton, Michael, Girard, Luc, Lai, Tsung-Po, Batten, Kimberly, Cornelius, Crystal, Dalvi, Maithili P., Ramirez, Michael, Du, Wenting, Wu, Lani F., Altschuler, Steven J., Brekken, Rolf, Martinez, Elisabeth D., Minna, John D., Wright, Woodring E., Shay, Jerry W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037876/
https://www.ncbi.nlm.nih.gov/pubmed/30015158
http://dx.doi.org/10.1016/j.neo.2018.06.002

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