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The Role of Biomaterials in Implantation for Central Nervous System Injury

Permanent deficits that occur in memory, sensation, and cognition can result from central nervous system (CNS) trauma that causes dysfunction and/or unregulated CNS regeneration. Some therapeutic approaches are preferentially applied to the human body. Therefore, cell transplantation, one of the the...

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Autores principales: Chen, Yu-Shuan, Harn, Horng-Jyh, Chiou, Tzyy-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038039/
https://www.ncbi.nlm.nih.gov/pubmed/29741115
http://dx.doi.org/10.1177/0963689717732991
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author Chen, Yu-Shuan
Harn, Horng-Jyh
Chiou, Tzyy-Wen
author_facet Chen, Yu-Shuan
Harn, Horng-Jyh
Chiou, Tzyy-Wen
author_sort Chen, Yu-Shuan
collection PubMed
description Permanent deficits that occur in memory, sensation, and cognition can result from central nervous system (CNS) trauma that causes dysfunction and/or unregulated CNS regeneration. Some therapeutic approaches are preferentially applied to the human body. Therefore, cell transplantation, one of the therapeutic strategies, may be used to benefit people. However, poor cell viability and low efficacy are the limitations to cell transplantation strategies. Biomaterials have been widely used in several fields (e.g., triggering cell differentiation, guiding cell migration, improving wound healing, and increasing tissue regeneration) by modulating their characteristics in chemistry, topography, and softness/stiffness for highly flexible application. We reviewed implanted biomaterials to investigate the roles and influences of physical/chemical properties on cell behaviors and applications. With their unique molecular features, biomaterials are delivered in several methods and mixed with transplanted cells, which assists in increasing postimplanted biological substance efficiency on cell survival, host responses, and functional recovery of animal models. Moreover, tracking the routes of these transplanted cells using biomaterials as labeling agents is crucial for addressing their location, distribution, activity, and viability. Here, we provide comprehensive comments and up-to-date research of the application of biomaterials.
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spelling pubmed-60380392018-07-11 The Role of Biomaterials in Implantation for Central Nervous System Injury Chen, Yu-Shuan Harn, Horng-Jyh Chiou, Tzyy-Wen Cell Transplant Reviews Permanent deficits that occur in memory, sensation, and cognition can result from central nervous system (CNS) trauma that causes dysfunction and/or unregulated CNS regeneration. Some therapeutic approaches are preferentially applied to the human body. Therefore, cell transplantation, one of the therapeutic strategies, may be used to benefit people. However, poor cell viability and low efficacy are the limitations to cell transplantation strategies. Biomaterials have been widely used in several fields (e.g., triggering cell differentiation, guiding cell migration, improving wound healing, and increasing tissue regeneration) by modulating their characteristics in chemistry, topography, and softness/stiffness for highly flexible application. We reviewed implanted biomaterials to investigate the roles and influences of physical/chemical properties on cell behaviors and applications. With their unique molecular features, biomaterials are delivered in several methods and mixed with transplanted cells, which assists in increasing postimplanted biological substance efficiency on cell survival, host responses, and functional recovery of animal models. Moreover, tracking the routes of these transplanted cells using biomaterials as labeling agents is crucial for addressing their location, distribution, activity, and viability. Here, we provide comprehensive comments and up-to-date research of the application of biomaterials. SAGE Publications 2018-05-09 2018-03 /pmc/articles/PMC6038039/ /pubmed/29741115 http://dx.doi.org/10.1177/0963689717732991 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Chen, Yu-Shuan
Harn, Horng-Jyh
Chiou, Tzyy-Wen
The Role of Biomaterials in Implantation for Central Nervous System Injury
title The Role of Biomaterials in Implantation for Central Nervous System Injury
title_full The Role of Biomaterials in Implantation for Central Nervous System Injury
title_fullStr The Role of Biomaterials in Implantation for Central Nervous System Injury
title_full_unstemmed The Role of Biomaterials in Implantation for Central Nervous System Injury
title_short The Role of Biomaterials in Implantation for Central Nervous System Injury
title_sort role of biomaterials in implantation for central nervous system injury
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038039/
https://www.ncbi.nlm.nih.gov/pubmed/29741115
http://dx.doi.org/10.1177/0963689717732991
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