Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic health, yet the dynamic processes that evoke this response are poorly understood. Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining...

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Detalles Bibliográficos
Autores principales: Sustarsic, Elahu G., Ma, Tao, Lynes, Matthew D., Larsen, Michael, Karavaeva, Iuliia, Havelund, Jesper F., Nielsen, Carsten H., Jedrychowski, Mark P., Moreno-Torres, Marta, Lundh, Morten, Plucinska, Kaja, Jespersen, Naja Z., Grevengoed, Trisha J., Kramar, Barbara, Peics, Julia, Hansen, Jakob B., Shamsi, Farnaz, Forss, Isabel, Neess, Ditte, Keipert, Susanne, Wang, Jianing, Stohlmann, Katharina, Brandslund, Ivan, Christensen, Cramer, Jørgensen, Marit E., Linneberg, Allan, Pedersen, Oluf, Kiebish, Michael A., Qvortrup, Klaus, Han, Xianlin, Pedersen, Bente Klarlund, Jastroch, Martin, Mandrup, Susanne, Kjær, Andreas, Gygi, Steven P., Hansen, Torben, Gillum, Matthew P., Grarup, Niels, Emanuelli, Brice, Nielsen, Søren, Scheele, Camilla, Tseng, Yu-Hua, Færgeman, Nils J., Gerhart-Hines, Zachary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038052/
https://www.ncbi.nlm.nih.gov/pubmed/29861389
http://dx.doi.org/10.1016/j.cmet.2018.05.003

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