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Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population
This study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) in a Chinese biopsy population. A total of 2355 men who underwent initial prostate biopsy from January 2006 to November 2015 in Huashan Hospital were recruited in the current...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038173/ https://www.ncbi.nlm.nih.gov/pubmed/29405172 http://dx.doi.org/10.4103/aja.aja_81_17 |
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author | Wu, Yi-Shuo Wu, Xiao-Bo Zhang, Ning Jiang, Guang-Liang Yu, Yang Tong, Shi-Jun Jiang, Hao-Wen Mao, Shan-Hua Na, Rong Ding, Qiang |
author_facet | Wu, Yi-Shuo Wu, Xiao-Bo Zhang, Ning Jiang, Guang-Liang Yu, Yang Tong, Shi-Jun Jiang, Hao-Wen Mao, Shan-Hua Na, Rong Ding, Qiang |
author_sort | Wu, Yi-Shuo |
collection | PubMed |
description | This study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) in a Chinese biopsy population. A total of 2355 men who underwent initial prostate biopsy from January 2006 to November 2015 in Huashan Hospital were recruited in the current study. The PSA-AV scores were calculated and assessed together with PSA and PSA density (PSAD) retrospectively. Among 2133 patients included in the analysis, 947 (44.4%) were diagnosed with PCa. The mean age, PSA, and positive rates of digital rectal examination result and transrectal ultrasound result were statistically higher in men diagnosed with PCa (all P < 0.05). The values of area under the receiver operating characteristic curves (AUCs) of PSAD and PSA-AV were 0.864 and 0.851, respectively, in predicting PCa in the entire population, both performed better than PSA (AUC = 0.805; P < 0.05). The superiority of PSAD and PSA-AV was more obvious in subgroup with PSA ranging from 2.0 ng ml(−1) to 20.0 ng ml(−1). A PSA-AV score of 400 had a sensitivity and specificity of 93.7% and 40.0%, respectively. In conclusion, the PSA-AV score performed equally with PSAD and was better than PSA in predicting PCa. This indicated that PSA-AV score could be a useful tool for predicting PCa in Chinese population. |
format | Online Article Text |
id | pubmed-6038173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60381732018-07-26 Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population Wu, Yi-Shuo Wu, Xiao-Bo Zhang, Ning Jiang, Guang-Liang Yu, Yang Tong, Shi-Jun Jiang, Hao-Wen Mao, Shan-Hua Na, Rong Ding, Qiang Asian J Androl Original Article This study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) in a Chinese biopsy population. A total of 2355 men who underwent initial prostate biopsy from January 2006 to November 2015 in Huashan Hospital were recruited in the current study. The PSA-AV scores were calculated and assessed together with PSA and PSA density (PSAD) retrospectively. Among 2133 patients included in the analysis, 947 (44.4%) were diagnosed with PCa. The mean age, PSA, and positive rates of digital rectal examination result and transrectal ultrasound result were statistically higher in men diagnosed with PCa (all P < 0.05). The values of area under the receiver operating characteristic curves (AUCs) of PSAD and PSA-AV were 0.864 and 0.851, respectively, in predicting PCa in the entire population, both performed better than PSA (AUC = 0.805; P < 0.05). The superiority of PSAD and PSA-AV was more obvious in subgroup with PSA ranging from 2.0 ng ml(−1) to 20.0 ng ml(−1). A PSA-AV score of 400 had a sensitivity and specificity of 93.7% and 40.0%, respectively. In conclusion, the PSA-AV score performed equally with PSAD and was better than PSA in predicting PCa. This indicated that PSA-AV score could be a useful tool for predicting PCa in Chinese population. Medknow Publications & Media Pvt Ltd 2018 2018-02-06 /pmc/articles/PMC6038173/ /pubmed/29405172 http://dx.doi.org/10.4103/aja.aja_81_17 Text en Copyright: © The Author(s)(2018) http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Wu, Yi-Shuo Wu, Xiao-Bo Zhang, Ning Jiang, Guang-Liang Yu, Yang Tong, Shi-Jun Jiang, Hao-Wen Mao, Shan-Hua Na, Rong Ding, Qiang Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population |
title | Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population |
title_full | Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population |
title_fullStr | Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population |
title_full_unstemmed | Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population |
title_short | Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population |
title_sort | evaluation of psa-age volume score in predicting prostate cancer in chinese population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038173/ https://www.ncbi.nlm.nih.gov/pubmed/29405172 http://dx.doi.org/10.4103/aja.aja_81_17 |
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